Recent Experience: Corticosteroids as a First-line Therapy in Children With Multisystem Inflammatory Syndrome and COVID-19-related Myocardial Damage

Conclusions: Among children with MIS-C with cardiovascular involvement, treatment with CS was associated with faster normalization of LV EF, fever, laboratory analysis, and shorter ICU than IVIG-treated patients.
Source: The Pediatric Infectious Disease Journal - Category: Infectious Diseases Tags: Original Studies Source Type: research

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We report the case of a patient with COVID-19–induced myocarditis who was successfully treated with dexamethasone and review the literature.
Source: Infectious Diseases in Clinical Practice - Category: Infectious Diseases Tags: Case Reports Source Type: research
COVID-19 disease has been a pandemic caused by a β-coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). A life-threatening multisystem inflammatory syndrome (MIS), secondary to SARS-CoV-2 virus infection, sharing common features with Kawasaki disease shock syndrome, staphylococcal/streptococcal shock syndrome, and macrophage activation syndrome in pediatric patients has been described. A total of 27 cases in adults (MIS-A) with a similar presentation have been reported so far. Here we describe the case of a 21-year-old man admitted with abdominal pain, diarrhea, tachycardia, and low blood pressure...
Source: Infectious Diseases in Clinical Practice - Category: Infectious Diseases Tags: Case Reports Source Type: research
ConclusionsAmong 56 post-COVID patients with persistent thoracic complaints final diagnosis of myocarditis could be confirmed in a single patient using CMR.Graphic abstract
Source: Clinical Research in Cardiology - Category: Cardiology Source Type: research
ConclusionsIn this autopsy cohort of COVID-19 patients, myocarditis is rarely found and not associated with SARS-CoV-2 presence in cardiomyocytes. Chronic and acute forms of myocardial damage are constantly found and correlate with the severity of COVID-19 disease and pre-existing comorbidities.Graphic abstract
Source: Clinical Research in Cardiology - Category: Cardiology Source Type: research
We read with interest the article “Socioeconomic and Racial and/or Ethnic Disparities in Multisystem Inflammatory Syndrome” by Javalkar et al.1 Multisystem inflammatory syndrome in children (MIS-C) is a potentially fatal complication of severe acute respiratory syndrome coronavirus 2 infection (coronavirus disease 2019 [COVID-19]) because patients can develop myocarditis, coronary artery abnormalities, arrhythmias, myocardial ischemia, cardiogenic shock, and death.2 Javalkar et  al demonstrated that children in Massachusetts with lower socioeconomic status and higher social vulnerability index (SVI) h...
Source: PEDIATRICS - Category: Pediatrics Source Type: research
Hamostaseologie. 2021 Oct;41(5):379-385. doi: 10.1055/a-1581-4355. Epub 2021 Oct 25.ABSTRACTIn 2019 first reports about a new human coronavirus emerged, which causes common cold symptoms as well as acute respiratory distress syndrome. The virus was identified as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and severe thrombotic events including deep vein thrombosis, pulmonary embolism, and microthrombi emerged as additional symptoms. Heart failure, myocardial infarction, myocarditis, and stroke have also been observed. As main mediator of thrombus formation, platelets became one of the key aspects in SARS-C...
Source: Hamostaseologie - Category: Hematology Authors: Source Type: research
Cardiac involvement in COVID-19 can range from mild damage to severe myocarditis. SARS-CoV-2 binds with high affinity to the human angiotensin-converting enzyme receptor 2 (ACE 2), which is expressed in the entire body, including the heart. Severe systemic manifestations, such as myocarditis, have been reported in association with the coronavirus disease 2019 (COVID-19) (Kerneis et al., 2020; Hamming et al., 2004). Some COVID-19 patients have persistent tachycardia, sustained asymptomatic hypotension, and bradycardia (Huang et al., 2020).
Source: International Journal of Infectious Diseases - Category: Infectious Diseases Authors: Tags: Case Report Source Type: research
CONCLUSION: The thromboembolic complications of COVID-19 may extend to CRVO, which in this case presented months after onset of symptoms of pneumonia, in association with myocarditis.PMID:34637677 | DOI:10.1080/09273948.2021.1977830
Source: Ocular Immunology and Inflammation - Category: Allergy & Immunology Authors: Source Type: research
Myocarditis is a potential complication after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and a known cause of sudden cardiac death. Given the athletic demands of soldiers, identific...
Source: Journal of Cardiovascular Magnetic Resonance - Category: Radiology Authors: Tags: Research Source Type: research
AbstractThorough postmortem investigations of fatalities following vaccination with coronavirus disease 2019 (COVID-19) vaccines are of great social significance. From 11.03.2021 to 09.06.2021, postmortem investigations of 18 deceased persons who recently received a vaccination against COVID-19 were performed. Vaxzevria was vaccinated in nine, Comirnaty in five, Spikevax in three, and Janssen in one person. In all cases, full autopsies, histopathological examinations, and virological analyses for the severe acute respiratory syndrome coronavirus 2 were carried out. Depending on the case, additional laboratory tests (anaphy...
Source: International Journal of Legal Medicine - Category: Medical Law Source Type: research
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