Pathogenic autoantibody derived from Treg-deficient scurfy mice targets Col7 and leads to Epidermolysis bullosa acquisita-like blistering disease

Autoimmune blistering diseases (AIBD) are severe human autoimmune diseases affecting the skin and mucous membranes (Witte et al., 2018). AIBD patients develop pathogenic autoantibodies targeting structural skin proteins and causing intraepidermal blisters to form as in pemphigus vulgaris (PV) or at the basement membrane zone (BMZ) as in pemphigoid diseases (Schmidt and Zillikens, 2011). For many AIBD, the events following autoantibody binding have been elucidated. However, early events in the pathogenic cascade leading to autoantibody production are still not fully understood.

Source: Journal of Investigative Dermatology - October 19, 2021 Category: Dermatology Authors: Elisabeth Vicari, Stefanie Haeberle, Vanessa Bolduan, Torben Ramcke, Artem Vorobyev, Stephanie Goletz, Hiroaki Iwata, Ralf J. Ludwig, Enno Schmidt, Alexander H. Enk, Eva N. Hadaschik Tags: Letters to the Editor Source Type: research