Cancers, Vol. 13, Pages 5246: Cancer-Associated Fibroblast Functions as a Road-Block in Cancer Therapy

Cancers, Vol. 13, Pages 5246: Cancer-Associated Fibroblast Functions as a Road-Block in Cancer Therapy Cancers doi: 10.3390/cancers13205246 Authors: Pradip De Jennifer Aske Nandini Dey The journey of a normal resident fibroblast belonging to the tumor microenvironment (TME) from being a tumor pacifier to a tumor patron is fascinating. We introduce cancer-associated fibroblast (CAF) as a crucial component of the TME. Activated-CAF partners with tumor cells and all components of TME in an established solid tumor. We briefly overview the origin, activation, markers, and overall functions of CAF with a particular reference to how different functions of CAF in an established tumor are functionally connected to the development of resistance to cancer therapy in solid tumors. We interrogate the role of CAF in mediating resistance to different modes of therapies. Functional diversity of CAF in orchestrating treatment resistance in solid tumors portrays CAF as a common orchestrator of treatment resistance; a roadblock in cancer therapy.
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Review Source Type: research