Cancers, Vol. 13, Pages 5235: DARPin_9-29-Targeted Gold Nanorods Selectively Suppress HER2-Positive Tumor Growth in Mice
Cancers, Vol. 13, Pages 5235: DARPin_9-29-Targeted Gold Nanorods Selectively Suppress HER2-Positive Tumor Growth in Mice
Cancers doi: 10.3390/cancers13205235
Authors:
Galina M. Proshkina
Elena I. Shramova
Marya V. Shilova
Ivan V. Zelepukin
Victoria O. Shipunova
Anastasia V. Ryabova
Sergey M. Deyev
Alexander B. Kotlyar
Near-infrared phototherapy has great therapeutic potential for cancer treatment. However, for efficient application, in vivo photothermal agents should demonstrate excellent stability in blood and targeted delivery to pathological tissue. Here, we demonstrated that stable bovine serum albumin-coated gold mini nanorods conjugated to a HER2-specific designed ankyrin repeat protein, DARPin_9-29, selectively accumulate in HER2-positive xenograft tumors in mice and lead to a strong reduction in the tumor size when being illuminated with near-infrared light. The results pave the way for the development of novel DARPin-based targeted photothermal therapy of cancer.
Source: Cancers - Category: Cancer & Oncology Authors: Galina M. Proshkina Elena I. Shramova Marya V. Shilova Ivan V. Zelepukin Victoria O. Shipunova Anastasia V. Ryabova Sergey M. Deyev Alexander B. Kotlyar Tags: Article Source Type: research