Cancers, Vol. 13, Pages 5238: A Recurrent STAT5BN642H Driver Mutation in Feline Alimentary T Cell Lymphoma
Cancers, Vol. 13, Pages 5238: A Recurrent STAT5BN642H Driver Mutation in Feline Alimentary T Cell Lymphoma
Cancers doi: 10.3390/cancers13205238
Authors:
Matthias Kieslinger
Alexander Swoboda
Nina Kramer
Patricia Freund
Barbara Pratscher
Heidi A. Neubauer
Ralf Steinborn
Birgitt Wolfesberger
Andrea Fuchs-Baumgartinger
Richard Moriggl
Iwan A. Burgener
Alimentary lymphomas arising from T cells are rare and aggressive malignancies in humans. In comparison, they represent the most common anatomical form of lymphoma in cats. Due to the low prevalence in humans, the underlying pathomechanism for these diseases is poorly characterised, limiting experimental analysis and therapeutic exploration. To date, activating mutations of the JAK/STAT core cancer pathway and particularly the STAT5B oncoprotein have been identified in human enteropathy-associated T cell lymphoma. Here, we describe a high homology of human and feline STAT3 and STAT5B proteins and strong conservation at the genomic level. Analysis of 42 samples of feline T cell alimentary lymphoma reveals broad activation of STAT3 and STAT5B. Screening for known activating mutations in STAT3 or STAT5B identifies the presence of the STAT5BN642H driver mutation in feline enteropathy-associated T cell lymphoma in 7 out of 42 (16.67%) samples in total. Regarding lymphoma subtypes, the majority of mutations with 5 out of 17 (29.41%) cases were found in feline enteropathy-associated lymphoma type II (EATL II). ...
Source: Cancers - Category: Cancer & Oncology Authors: Matthias Kieslinger Alexander Swoboda Nina Kramer Patricia Freund Barbara Pratscher Heidi A. Neubauer Ralf Steinborn Birgitt Wolfesberger Andrea Fuchs-Baumgartinger Richard Moriggl Iwan A. Burgener Tags: Article Source Type: research