Provision of folic acid for reducing arsenic toxicity in arsenic-exposed children and adults

CONCLUSIONS: There is moderate-certainty evidence that FA supplements may benefit blood arsenic concentration, urinary arsenic methylation profiles, and plasma homocysteine concentration versus placebo. There is low-certainty evidence that FA supplements plus other nutrients may benefit blood arsenic and plasma homocysteine concentrations versus nutrients alone. No studies reported on cancer, all-cause mortality, neurocognitive function, or congenital anomalies. Given the limited number of RCTs, more studies conducted in diverse settings are needed to assess the effects of FA on arsenic-related health outcomes and arsenic toxicity in arsenic-exposed adults and children.PMID:34661903 | DOI:10.1002/14651858.CD012649.pub2

Source: Cochrane Database of Systematic Reviews - October 18, 2021 Category: General Medicine Authors: Sajin Bae Elena Kamynina Heather M Guetterman Adetutu F Farinola Marie A Caudill Robert J Berry Patricia A Cassano Patrick J Stover Source Type: research