PTH 1 ‐34 Replacement Therapy Has Minimal Effect on Quality of Life in Patients With Hypoparathyroidism

In conclusion, hypoparathyroidism is associated with decreased QOL. Despite the bias in open-label studies to predict improvements in QOL, PTH therapy had limited and non-sustained effects on QOL, inconclusive changes in fatigue experience, and no change i n the 6MWT. Although PTH 1-34 can adequately manage the hypocalcemia in hypoparathyroidism, its effects on QOL appear to be minimal. © 2021 American Society for Bone and Mineral Research (ASBMR). This article has been contributed to by US Government employees and their work is in the public domain in the USA.

Source: Journal of Bone and Mineral Research - October 18, 2021 Category: Orthopaedics Authors: Kelly L. Roszko, Tiffany Y. Hu, Lori C. Guthrie, Beth A. Brillante, Michaele Smith, Michael T. Collins, Rachel I. Gafni Tags: Original Article Source Type: research