Why We Lose Weight and Why We Don't Why We Lose Weight and Why We Don't

According to the NIDDK, more than 70% of American adults are overweight or obese.WebMD Health News
Source: Medscape Infectious Diseases Headlines - Category: Infectious Diseases Tags: Diabetes & Endocrinology News Source Type: news

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CONCLUSIONS: A family T2DM prevention program was feasibly delivered by FQHC staff, and acceptable to mothers and children. Program efficacy will be evaluated in an adequately powered clinical trial.PMID:34866483 | DOI:10.1177/21501327211057643
Source: Primary Care - Category: Primary Care Authors: Source Type: research
CONCLUSION: The study demonstrates a strong correlation between maternal exposure to type1diabetes and higher risk of developing obesity, hypertension, dyslipidemia, eGFR, and microalbumiuria in the adolescent offspring.PMID:34866022 | DOI:10.1016/j.pcd.2021.11.008
Source: Primary Care - Category: Primary Care Authors: Source Type: research
Front Cardiovasc Med. 2021 Nov 19;8:669245. doi: 10.3389/fcvm.2021.669245. eCollection 2021.ABSTRACTBackground: We aimed to evaluate the relationship between metabolic syndrome (MetS) including its components and carotid intima media thickness (CIMT) in a low-income Chinese population aged ≥45 years. Methods: The participants underwent a general health screening and B-mode carotid ultrasonography that measured CIMT. The diagnosis of MetS and its components was based on the modified International Diabetes Federation Criteria for the Asian Population. The univariate and multivariable linear regression analyses were used t...
Source: Atherosclerosis - Category: Cardiology Authors: Source Type: research
Conclusions: Abdominoplasty is a common plastic surgery procedure associated with an increased risk for complications in certain patients. In our study,a high complication rate was observed, probably because our population was mostly obese and many cases needed an additional procedure. There are no clear guidelines for the surgeon to choose the best surgical candidate. However, risk factors should be taken into consideration, and explained to the patient before the surgical decision.PMID:34866546
Source: Acta Chirurgica Belgica - Category: Surgery Authors: Source Type: research
Endocr J. 2021 Dec 3. doi: 10.1507/endocrj.EJ21-0438. Online ahead of print.ABSTRACTInteletin1 (Itln1) is an adipokine that is abundantly expressed in intestine, ovary, and lung. The expression levels of ITLN1 are decreased in the presence of diabetes or obesity, but the mechanisms of its production and function are still controversial. The aim of this study is to elucidate the mechanisms of ITLN1 synthesis and ITLN1-associated macrophage activation. To analyze the effects of high fat and high-carbohydrate diet (HFHCD) on the expression of ITLN1 in the intestine, the mice were fed a HFHCD for 8 weeks. HFHCD feeding enhance...
Source: Endocrine Journal - Category: Endocrinology Authors: Source Type: research
Nature Reviews Endocrinology, Published online: 06 December 2021; doi:10.1038/s41574-021-00607-wIn 2021, clinical trials reported the promising effects of incretins and a new class of dual glucagon-like peptide 1–glucose-dependent insulinotropic peptide receptor agonists in preventing and treating type 2 diabetes mellitus and obesity. These ‘twincretins’ will transform the prevention of obesity and type 2 diabetes mellitus and the care of people with these conditions.
Source: Nature Reviews Endocrinology - Category: Endocrinology Authors: Source Type: research
In this study, they found these drugs can kill senescent cells from cultures of human fat tissue. The tissue was donated by individuals with obesity who were known to have metabolic troubles. Without treatment, the human fat tissues induced metabolic problems in immune-deficient mice. After treatment with dasatinib and quercetin, the harmful effects of the fat tissue were almost eliminated. Targeting p21Cip1 highly expressing cells in adipose tissue alleviates insulin resistance in obesity Insulin resistance is a pathological state often associated with obesity, representing a major risk factor for type 2...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
J Clin Endocrinol Metab. 2021 Dec 5:dgab848. doi: 10.1210/clinem/dgab848. Online ahead of print.ABSTRACTIn treating obesity as a chronic disease, the essential goal of weight loss therapy is not the quantity of weight loss as an end unto itself, but rather the prevention and treatment of complications to enhance health and mitigate morbidity and mortality. This perspective on obesity care is consistent with the complications-centric AACE obesity guidelines and the diagnostic term of Adiposity-Based Chronic Disease (ABCD). Many complications require 10-20% weight loss to achieve therapeutic goals; however, existing obesity ...
Source: The Journal of Clinical Endocrinology and Metabolism - Category: Endocrinology Authors: Source Type: research
CONCLUSION: The interaction between SARS-CoV-2 and the heart is complex and is manifested in multiple ways. Regardless of the clinical presentation, cardiac complications convey a worse prognosis. Patients should be actively monitored and treated accordingly.PMID:34863324 | DOI:10.20344/amp.15584
Source: Acta Medica Portuguesa - Category: General Medicine Authors: Source Type: research
Curr Opin Pharmacol. 2021 Dec 2;62:4-11. doi: 10.1016/j.coph.2021.10.004. Online ahead of print.ABSTRACTThe cardiometabolic disorder (CMD) is a syndrome caused by coalescing of cardiovascular, endocrine, pro-thrombotic, and inflammatory health risks. Together, these risks confer a hazard as health-threatening as coronary artery disease or type2 diabetes, whether an individual has a diagnosis of coronary disease or diabetes, or not. CMD is most often defined by three or more of five clinically assessed risk components, notably obesity, insulin resistance, hypertension, hypertriglyceridemia, and depressed high-density lipopr...
Source: Current Opinion in Pharmacology - Category: Drugs & Pharmacology Authors: Source Type: research
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