Incidence and Mortality of Malignant Melanoma in Relation to Dermatologist Density in Bavaria

ConclusionThe dermatologist density in Bavaria correlates positively with the incidence of malignant melanoma. Despite an increased incidence, mortality was not elevated in the respective administrative regions.
Source: Advances in Therapy - Category: Drugs & Pharmacology Source Type: research

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Oncol Lett. 2022 Jan;23(1):29. doi: 10.3892/ol.2021.13147. Epub 2021 Nov 23.ABSTRACTThe growing importance of antitumour immunity by cancer immunotherapy has prompted studies on radiotherapy-induced immune response. Previous studies have indicated that programmed cell death-1 ligand (PD-L1) expression is regulated by DNA damage signalling. However, PD-L1 up-regulation after radiotherapy has not been fully investigated at the clinical level, particularly in the context of expression of DNA repair factors. The present study examined the correlation of mRNA expression between PD-L1 and non-homologous end joining (NHEJ) factor...
Source: Oncology Letters - Category: Cancer & Oncology Authors: Source Type: research
CONCLUSIONS: Based on this updated review, the current literature does not provide evidence that suggests a survival benefit from adding immunotherapy (excluding checkpoint inhibitors) to conventional curative surgery or radiotherapy, for people with localised NSCLC (stages I to III). Several ongoing trials with immune checkpoints inhibitors (PD-1/PD-L1) might bring new insights into the role of immunotherapy for people with stages I to III NSCLC.PMID:34870327 | DOI:10.1002/14651858.CD011300.pub3
Source: Cancer Control - Category: Cancer & Oncology Authors: Source Type: research
Eigentler Peter Martus (1) Background: Immune checkpoint inhibitors have improved the prognosis of patients with advanced melanoma. Published data suggested that the objective response rates appear to be superior in patients who developed immune-related adverse events (irAEs). (2) The primary aim of this cohort study was to evaluate the association between irAEs and disease control rate in patients with stage IV melanoma treated with first-line PD-1-based immunotherapy. (3) Among 319 patients, 53% experienced at least one irAE. A higher percentage of patients with irAEs had disease control compared to those without i...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
Upregulation of the adaptor protein NUMB triggers melanocytic differentiation from multipotent skin stem cells, which share many properties with aggressive melanoma cells. Although NUMB acts as a tumor suppressor in various human cancer types, little is known about its role in melanoma. Here, we investigated the role of NUMB in melanoma progression and its regulatory mechanism. Analysis of The Cancer Genome Atlas melanoma datasets revealed that high NUMB expression in melanoma tissues correlates with improved patient survival.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Original Article Source Type: research
ridou Basosquamous carcinoma is a rare, aggressive non-melanoma skin cancer with features that lie between those of basal cell carcinoma and squamous cell carcinoma. A lot of controversy has been raised around the classification, pathogenesis, histologic morphology, biologic behavior, prognosis and management of this tumor. This is a narrative review based on an electronic search of articles published in PubMed in English language which had in their title the terms “basosquamous carcinoma” and/or “metatypical carcinoma of the skin”. The aim of this review was to summarize and eva...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Commentary Source Type: research
Cristiana Picco Potassium channels have emerged as regulators of carcinogenesis, thus introducing possible new therapeutic strategies in the fight against cancer. In particular, the large-conductance Ca2+-activated K+ channel, often referred to as BK channel, is involved in several cancer-associated processes. Here, we investigated the effects of different BK activators, NS-11021, NS-19504, and BMS-191011, in IGR39 (primary melanoma cell line) and Panc-1 (primary pancreatic duct carcinoma cell line), highly expressing the channel, and in IGR37 (metastatic melanoma cell line) that barely express BK. Our data showed that...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
In this study, they found these drugs can kill senescent cells from cultures of human fat tissue. The tissue was donated by individuals with obesity who were known to have metabolic troubles. Without treatment, the human fat tissues induced metabolic problems in immune-deficient mice. After treatment with dasatinib and quercetin, the harmful effects of the fat tissue were almost eliminated. Targeting p21Cip1 highly expressing cells in adipose tissue alleviates insulin resistance in obesity Insulin resistance is a pathological state often associated with obesity, representing a major risk factor for type 2...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Skinmed. 2021 Oct 1;19(5):334-336. eCollection 2021.ABSTRACTMost conditions and diseases have one or more features that are essential for recognizing the most common presentations of the disease. Melanoma is a cancer of pigment-producing cells, and the term "melanoma" is derived from the Greek term for "dark tumor." Many, if not most, descriptions of melanomas include their being in general dark brown or black; however, the most utilized set of criteria for melanoma education, the ABCDE (asymmetry, border irregularity, color variation, diameter> 6mm, evolving) criteria, omits darkness as even one of ...
Source: Skinmed - Category: Dermatology Authors: Source Type: research
SKIN cancer is one of the most common cancers worldwide, with 147,000 new cases of non-melanoma skin cancer diagnosed in the UK every year. Express.co.uk spoke to a skin expert about a mistake to avoid that could lead to this condition even in winter.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
On behalf of my coauthors, I thank Dr Hersey for his insightful analysis of our manuscript describing pyrexia characteristics in patients treated with dabrafenib plus trametinib, a topic of critical importance given that pyrexia is the most common adverse event associated with this treatment combination. The goal of our manuscript was to describe pyrexia incidence and management patterns among patients who received dabrafenib plus trametinib in clinical trials. Notably, the 1076 patients included in our analysis encompassed those with advanced non-small cell lung cancer (n  = 82), stage III resectable melanoma (n...
Source: European Journal of Cancer - Category: Cancer & Oncology Authors: Tags: Author ’s reply Source Type: research
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