Sedation Effects Produced by a Ciprofol Initial Infusion or Bolus Dose Followed by Continuous Maintenance Infusion in Healthy Subjects: A Phase 1 Trial

ConclusionCiprofol has potential for clinical application for continuous intravenous infusion to maintain sedation for 12  h with the same safety, tolerability and efficacy as propofol.
Source: Advances in Therapy - Category: Drugs & Pharmacology Source Type: research

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Conclusion One of the ways to ensure you lead a happy and quality life is to take good care of your mental health continually. Practicing the habits discussed above will take you a step forward in staying mentally healthy. Do you have any bad mental health habits you struggle with? Can you commit to kicking them to the curb and practicing the above helpful mental health habits? We would appreciate your feedback in the comment section.   Sherry Kimball likes to write articles with advice that help people to improve their lives.  Sherry enjoys researching, discussing, and writing on the topics of ...
Source: PickTheBrain | Motivation and Self Improvement - Category: Consumer Health News Authors: Tags: featured happiness psychology habits mental health Source Type: blogs
Expert Rev Neurother. 2021 Nov 30. doi: 10.1080/14737175.2022.2012156. Online ahead of print.ABSTRACTINTRODUCTION: : The widespread use of the word "placebo" in the medical literature emphasizes the importance of this phenomenon in modern biomedical sciences. Neuroscientific research over the past thirty years shows that placebo effects are genuine psychobiological events attributable to the overall therapeutic context, and can be robust in both laboratory and clinical settings.AREAS COVERED: : Here the authors describe the biological mechanisms and the clinical implications of placebo effects with particular emp...
Source: Expert Review of Neurotherapeutics - Category: Neurology Authors: Source Type: research
The objective of this study was to examine ongoing symptoms, functional limitations and quality of life over time in a cohort of individuals who were deemed to have recovered.METHOD: This was a prospective observational study on biopsychosocial outcomes at enrolment and again one month later.RESULTS: In a cohort of 59 participants, ongoing symptoms were reported by 73% at 4.5 months (standard deviation = 1.4) post diagnosis, with 45% reporting difficulty with pre-illness activities of daily living. Of the 52 participants who completed the follow-up survey (mean 5.6 months post diagnosis), 42% reported ongoing symptoms, low...
Source: Pain Physician - Category: Anesthesiology Authors: Source Type: research
In this study, we aimed to investigate the anemia-independent impact of MDS on HRQoL. We evaluated participants ( ≥ 50 years) from the large population-based Lifelines cohort (N = 44,694, mean age 59.0 ± 7.4 years, 43.6% male) and the European MDS Registry (EUMDS) (N = 1538, mean age 73.4 ± 9.0 years, 63.0% male), which comprises a cohort of lower-risk MDS patients. To enable comparison concerning HRQoL, SF-36 scores measured in Lifelines were converted to EQ-5D-3L index (range 0–1) and dimension scores. Lower-risk MDS pati...
Source: Annals of Hematology - Category: Hematology Source Type: research
Her husband died by suicide. She sued his pain doctors He died by suicide. In an unusual step, his wife sued his pain doctors — a rare legal challenge to decisions to reduce patients’ opioid doses www.statnews.com
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: Pain Medicine Source Type: forums
In conclusion, myalgia at the acute phase was associated with musculoskeletal pain as long-term post-COVID sequelae. In addition, half of the patients with preexisting pain conditions experienced a persistent exacerbation of their previous syndromes.
Source: Pain - Category: Anesthesiology Tags: Research Paper Source Type: research
CONCLUSIONS: Application areas and effects of WATSU are consistently employed practically and scientifically. Respondents' ratings of effectiveness of WATSU match tentative research efforts. WATSU is cautiously recommended for the use in pain- and stress-related conditions. Short- and long-term effectiveness of WATSU need to be evaluated in high level intervention studies.PMID:34844068 | DOI:10.1016/j.ctcp.2021.101513
Source: Complementary Therapies in Clinical Practice - Category: Complementary Medicine Authors: Source Type: research
J Palliat Care. 2021 Nov 29:8258597211049592. doi: 10.1177/08258597211049592. Online ahead of print.ABSTRACTObjectives: Patients with chronic respiratory insufficiency suffer from advanced disease, but their overall symptom burden is poorly described. We evaluated the symptoms and screening of depression in subjects with chronic respiratory insufficiency by using the Edmonton symptom assessment system (ESAS). Methods: In this retrospective study, 226 subjects with chronic respiratory insufficiency answered the ESAS questionnaire measuring symptoms on a scale from 0 (no symptoms) to 10 (worst possible symptom), and the depr...
Source: Journal of Palliative Care - Category: Palliative Care Authors: Source Type: research
Reduction of the incidence of depression and improvement of quality of life (QOL) of elderly people have become important subjects. Various factors are related to depressive symptoms in elderly people, and sensory impairment is a key to health, QOL, and de...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Elder Adults Source Type: news
eacute; Mark P. Jensen Jordi Miró Electronic health literacy skills and competences are important for empowering people to have an active role in making appropriate health care decisions. The aims of this cross-sectional study were to (1) examine the frequency of use of the Internet for seeking online information about chronic pain, (2) determine the level of eHealth literacy skills in the study sample, (3) identify the factors most closely associated with higher levels of eHealth literacy, and (4) examine self-efficacy as a potential mediator of the association between eHealth literacy and measures of pain ...
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research
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