Reply to: Multiple Comparisons and Inappropriate Statistical Testing Lead to Spurious Sex Differences in Gene Expression

In our recent publication (1), we used RNA sequencing of several limbic brain regions to identify sex-specific transcriptional profiles in response to cocaine that are disrupted by adolescent experience. RNA sequencing provides a powerful approach to investigate transcription on a global scale and has been instrumental in contributing to an improved understanding of brain function in recent years. For example, our laboratories have successfully employed transcriptomic analyses to identify novel key drivers important for regulating behavioral and neural abnormalities associated with stress- and addiction-related disorders [e.g., (2 –7)].
Source: Biological Psychiatry - Category: Psychiatry Authors: Tags: Correspondence Source Type: research