Possible mechanisms of cholesterol elevation aggravating COVID-19

Conclusions and Relevance: Cholesterol can indirectly increase the susceptibility of patients to SARS-CoV-2 and increase the risk of death from COVID-19, which are mediated by NLRP3 and atherosclerotic plaques, respectively. Cholesterol present in the host cell membrane, virus, and blood may also directly participate in the virus cell entry process, but the specific mechanism still needs further study. Patients with COVID-19 are recommended to continue lipid-lowering therapy.PMID:34522180 | PMC:PMC8436106 | DOI:10.7150/ijms.62021
Source: International Journal of Medical Sciences - Category: Biomedical Science Authors: Source Type: research