Molecular insights into mechanisms of GPCR hijacking by Staphylococcus aureus [Biochemistry]

Atypical chemokine receptor 1 (ACKR1) is a G protein–coupled receptor (GPCR) targeted by Staphylococcus aureus bicomponent pore-forming leukotoxins to promote bacterial growth and immune evasion. Here, we have developed an integrative molecular pharmacology and structural biology approach in order to characterize the effect of leukotoxins HlgA and HlgB on ACKR1...

Source: Proceedings of the National Academy of Sciences - October 18, 2021 Category: Science Authors: Claire M. Grison, Paul Lambey, Sylvain Jeannot, Elise Del Nero, Simon Fontanel, Fanny Peysson, Joyce Heuninck, Remy Sounier, Thierry Durroux, Cedric Leyrat, Sebastien Granier, Cherine Bechara Tags: Biochemistry Biological Sciences Source Type: research