Critical regulation of follicular helper T cell differentiation and function by G{alpha}13 signaling [Immunology and Inflammation]
GPCR-Gα protein–mediated signal transduction contributes to spatiotemporal interactions between immune cells to fine-tune and facilitate the process of inflammation and host protection. Beyond this, however, how Gα proteins contribute to the helper T cell subset differentiation and adaptive response have been underappreciated. Here, we found that Gα13 signaling in T...
Source: Proceedings of the National Academy of Sciences - Category: Science Authors: Da-Sol Kuen, Miso Park, Heeju Ryu, Garam Choi, Young-Hye Moon, Jae-Ouk Kim, Keon Wook Kang, Sang Geon Kim, Yeonseok Chung Tags: Immunology and Inflammation Biological Sciences Source Type: research