Validating the NIH LDL-C Equation in a Specialized Lipid Cohort: Does it Add Up?

CONCLUSIONS: We validated the NIH equation against ultracentrifugation in a cohort with a wide lipid concentration range, which supported its superiority over the Friedewald equation. We recommend clinical implementing the NIH equation for all patients except those with type III hyperlipoproteinemia or TG >9.04 mmol/L, with an LDL-C lower reporting limit of <0.50 mmol/L.PMID:34656564 | DOI:10.1016/j.clinbiochem.2021.10.003

Source: Clinical Biochemistry - October 17, 2021 Category: Biochemistry Authors: Victoria Higgins Lawrence A Leiter Sarah R Delaney Daniel R Beriault Source Type: research