Cancers, Vol. 13, Pages 5211: The Prognostic Impact of Histology in Esophageal and Esophago-Gastric Junction Adenocarcinoma

Cancers, Vol. 13, Pages 5211: The Prognostic Impact of Histology in Esophageal and Esophago-Gastric Junction Adenocarcinoma Cancers doi: 10.3390/cancers13205211 Authors: Roberto Fiocca Luca Mastracci Marialuisa Lugaresi Federica Grillo Antonietta D’Errico Deborah Malvi Paola Spaggiari Anna Tomezzoli Luca Albarello Ari Ristimäki Luca Bottiglieri Elena Bonora Kausilia K. Krishnadath Gian Domenico Raulli Riccardo Rosati Uberto Fumagalli Romario Giovanni De Manzoni Jari Räsänen Sandro Mattioli Stage significantly affects survival of esophageal and esophago-gastric junction adenocarcinomas (EA/EGJAs), however, limited evidence for the prognostic role of histologic subtypes is available. The aim of the study was to describe a morphologic approach to EA/EGJAs and assess its discriminating prognostic power. Histologic slides from 299 neoadjuvant treatment-naïve EA/EGJAs, resected in five European Centers, were retrospectively reviewed. Morphologic features were re-assessed and correlated with survival. In glandular adenocarcinomas (240/299 cases—80%), WHO grade and tumors with a poorly differentiated component ≥6% were the most discriminant factors for survival (both p < 0.0001), distinguishing glandular well-differentiated from poorly differentiated adenocarcinomas. Two prognostically different histologic groups were identified: the lower risk group, comprising glandular well-differentiated (34.4%) and rare variants, s...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research