Cancers, Vol. 13, Pages 5211: The Prognostic Impact of Histology in Esophageal and Esophago-Gastric Junction Adenocarcinoma
Cancers, Vol. 13, Pages 5211: The Prognostic Impact of Histology in Esophageal and Esophago-Gastric Junction Adenocarcinoma
Cancers doi: 10.3390/cancers13205211
Authors:
Roberto Fiocca
Luca Mastracci
Marialuisa Lugaresi
Federica Grillo
Antonietta D’Errico
Deborah Malvi
Paola Spaggiari
Anna Tomezzoli
Luca Albarello
Ari Ristimäki
Luca Bottiglieri
Elena Bonora
Kausilia K. Krishnadath
Gian Domenico Raulli
Riccardo Rosati
Uberto Fumagalli Romario
Giovanni De Manzoni
Jari Räsänen
Sandro Mattioli
Stage significantly affects survival of esophageal and esophago-gastric junction adenocarcinomas (EA/EGJAs), however, limited evidence for the prognostic role of histologic subtypes is available. The aim of the study was to describe a morphologic approach to EA/EGJAs and assess its discriminating prognostic power. Histologic slides from 299 neoadjuvant treatment-naïve EA/EGJAs, resected in five European Centers, were retrospectively reviewed. Morphologic features were re-assessed and correlated with survival. In glandular adenocarcinomas (240/299 cases—80%), WHO grade and tumors with a poorly differentiated component ≥6% were the most discriminant factors for survival (both p < 0.0001), distinguishing glandular well-differentiated from poorly differentiated adenocarcinomas. Two prognostically different histologic groups were identified: the lower risk group, comprising glandular well-differentiated (34.4%) and rare variants, s...
Source: Cancers - Category: Cancer & Oncology Authors: Roberto Fiocca Luca Mastracci Marialuisa Lugaresi Federica Grillo Antonietta D ’Errico Deborah Malvi Paola Spaggiari Anna Tomezzoli Luca Albarello Ari Ristim äki Luca Bottiglieri Elena Bonora Kausilia K. Krishnadath Gian Domenico Raulli Riccardo Rosati Tags: Article Source Type: research
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