Cancers, Vol. 13, Pages 5216: Molecular Targets for Gastric Cancer Treatment and Future Perspectives from a Clinical and Translational Point of View

Cancers, Vol. 13, Pages 5216: Molecular Targets for Gastric Cancer Treatment and Future Perspectives from a Clinical and Translational Point of View Cancers doi: 10.3390/cancers13205216 Authors: Justus Körfer Florian Lordick Ulrich T. Hacker Gastric cancer is a leading cause of cancer death worldwide. Systemic treatment comprising chemotherapy and targeted therapy is the standard of care in advanced/metastatic gastric cancer. Comprehensive molecular characterization of gastric adenocarcinomas by the TCGA Consortium and ACRG has resulted in the definition of distinct molecular subtypes. These efforts have in parallel built a basis for the development of novel molecularly stratified treatment approaches. Based on this molecular characterization, an increasing number of specific genomic alterations can potentially serve as treatment targets. Consequently, the development of promising compounds is ongoing. In this review, key molecular alterations in gastric and gastroesophageal junction cancers will be addressed. Finally, the current status of the translation of targeted therapy towards clinical applications will be reviewed.
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Review Source Type: research