Deep Brain Stimulation for Obsessive-Compulsive Disorder: Why Anatomy Matters

It has now been 21 years since the first publication discussed deep brain stimulation (DBS) for obsessive-compulsive disorder (OCD) (1), which targeted a well-established ablation site, the anterior limb of the internal capsule (ALIC). Building on the hypothesis that high-frequency stimulation equals ablation, first introduced for tremor in Parkinson ’s disease in the late 1980s, the application of DBS for a variety of neuropsychiatry disorders has been evolving ever since. The initial and somewhat naïve hypothesis was that DBS merely provided a safer, adjustable, and reversible lesion.
Source: Biological Psychiatry - Category: Psychiatry Authors: Tags: Commentary Source Type: research