In Utero Exposure to Metformin Reduces the Fertility of Male Offspring in Adulthood

In conclusion, while foetal metformin exposure did not dramatically alter gonad development, these results suggest that metabolic modification by metformin during the foetal period could change the expression of epigenetic regulators such as Tet1 and perturb the genomic DNA in germ cells, changes that might contribute to a reduced fertility.
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research