Metabolic Consequences of Neuronal HIF1 α-Deficiency in Mediobasal Hypothalamus in Mice

ConclusionsThe hypothalamic neuronal HIF1α plays an important role in the regulation of body weight balance in mice under normoxic condition. In the absence of hypothalamic neuronal HIF1α, the mice gained weight with increased appetite, accompanied with abnormal glucose and lipid metabolism. POMC and Glut4 may be responsible for this effect of HIF1α.
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research