Cancers, Vol. 13, Pages 5206: The Key Differences between Human Papillomavirus-Positive and -Negative Head and Neck Cancers: Biological and Clinical Implications
Cancers, Vol. 13, Pages 5206: The Key Differences between Human Papillomavirus-Positive and -Negative Head and Neck Cancers: Biological and Clinical Implications
Cancers doi: 10.3390/cancers13205206
Authors:
Steven F. Powell
Lexi Vu
William C. Spanos
Dohun Pyeon
Head and neck squamous cell carcinoma (HNSCC) is a unique malignancy associated with two distinct risk factors: exposure to typical carcinogens and infection of human papillomavirus (HPV). HPV encodes the potent oncoproteins E6 and E7, which bypass many important oncogenic processes and result in cancer development. In contrast, HPV-negative HNSCC is developed through multiple mutations in diverse oncogenic driver genes. While the risk factors associated with HPV-positive and HPV-negative HNSCCs are discrete, HNSCC patients still show highly complex molecular signatures, immune infiltrations, and treatment responses even within the same anatomical subtypes. Here, we summarize the current understanding of biological mechanisms, treatment approaches, and clinical outcomes in comparison between HPV-positive and -negative HNSCCs.
Source: Cancers - Category: Cancer & Oncology Authors: Steven F. Powell Lexi Vu William C. Spanos Dohun Pyeon Tags: Review Source Type: research
More News: Cancer | Cancer & Oncology | Carcinoma | Genetics | Genital Warts | Head and Neck Cancer | HNSCC | Human Papillomavirus (HPV) | Molecular Biology | Skin Cancer | Squamous Cell Carcinoma