Cancers, Vol. 13, Pages 5207: Improved Immunotherapy Efficacy by Vascular Modulation

Cancers, Vol. 13, Pages 5207: Improved Immunotherapy Efficacy by Vascular Modulation Cancers doi: 10.3390/cancers13205207 Authors: Emma L. Newport Ana Rita Pedrosa Alexandra Njegic Kairbaan M. Hodivala-Dilke José M. Muñoz-Félix Several strategies have been developed to modulate the tumour vasculature for cancer therapy including anti-angiogenesis and vascular normalisation. Vasculature modulation results in changes to the tumour microenvironment including oxygenation and immune cell infiltration, therefore lending itself to combination with cancer therapy. The development of immunotherapies has led to significant improvements in cancer treatment. Particularly promising are immune checkpoint blockade and CAR T cell therapies, which use antibodies against negative regulators of T cell activation and T cells reprogrammed to better target tumour antigens, respectively. However, while immunotherapy is successful in some patients, including those with advanced or metastatic cancers, only a subset of patients respond. Therefore, better predictors of patient response and methods to overcome resistance warrant investigation. Poor, or periphery-limited, T cell infiltration in the tumour is associated with poor responses to immunotherapy. Given that (1) lymphocyte recruitment requires leucocyte–endothelial cell adhesion and (2) the vasculature controls tumour oxygenation and plays a pivotal role in T cell infiltration and activation, vessel targeting strategies incl...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Review Source Type: research