Cancers, Vol. 13, Pages 5208: Landscape of 4D Cell Interaction in Hodgkin and Non-Hodgkin Lymphomas

Cancers, Vol. 13, Pages 5208: Landscape of 4D Cell Interaction in Hodgkin and Non-Hodgkin Lymphomas Cancers doi: 10.3390/cancers13205208 Authors: Sylvia Hartmann Sonja Scharf Yvonne Steiner Andreas G. Loth Emmanuel Donnadieu Nadine Flinner Viola Poeschel Stephanie Angel Moritz Bewarder Julia Bein Uta Brunnberg Alessandro Bozzato Bernhard Schick Stephan Stilgenbauer Rainer M. Bohle Lorenz Thurner Martin-Leo Hansmann Profound knowledge exists about the clinical, morphologic, genomic, and transcriptomic characteristics of most lymphoma entities. However, information is currently lacking on the dynamic behavior of malignant lymphomas. This pilot study aimed to gain insight into the motility of malignant lymphomas and bystander cells in 20 human lymph nodes. Generally, B cells were faster under reactive conditions compared with B cells in malignant lymphomas. In contrast, PD1-positive T cells did not show systematic differences in velocity between reactive and neoplastic conditions in general. However, lymphomas could be divided into two groups: one with fast PD1-positive T cells (e.g., Hodgkin lymphoma and mantle cell lymphoma; means 8.4 and 7.8 µm/min) and another with slower PD1-positive T cells (e.g., mediastinal grey zone lymphoma; mean 3.5 µm/min). Although the number of contacts between lymphoma cells and PD1-positive T cells was similar in different lymphoma types, important differences were observed in the duration of these contac...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research