PLK1 Inhibition Induces Immunogenic Cell Death and Enhances Immunity against NSCLC

In this study, we found that inhibiting PLK1 could alter the tumor immune microenvironment by increasing DC maturation, and enriching T cells infiltration. PLK1 inhibitors, serving as immunogenic cell death (ICD) inducers, indirectly activated DCs, instead of directly acting on DC cells, through the surface expression of costimulatory molecules on and enhanced phagocytosis by DCs. Furthermore, upon targeting PLK1, tumor cells that had undergone ICD were converted into an endogenous vaccine, which triggered the immune memory responses and protected the mice from tumor challenge. Collectively, these results suggested that the PLK1 inhibitor might function as an immune modulator in antitumor treatment.PMID:34522178 | PMC:PMC8436107 | DOI:10.7150/ijms.60135
Source: International Journal of Medical Sciences - Category: Biomedical Science Authors: Source Type: research