Trivalent inactivated seasonal influenza vaccine effectiveness for the prevention of laboratory-confirmed influenza in a Scottish population 2000 to 2009.

Trivalent inactivated seasonal influenza vaccine effectiveness for the prevention of laboratory-confirmed influenza in a Scottish population 2000 to 2009. Euro Surveill. 2015;20(8) Authors: Simpson C, Lone N, Kavanagh K, Ritchie L, Robertson C, Sheikh A, McMenamin J PMID: 25742433 [PubMed - in process]
Source: Euro Surveill - Category: Infectious Diseases Authors: Tags: Euro Surveill Source Type: research

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Conditions:   Flu, Human;   Influenza, Human Intervention:   Behavioral: Video about safety and effectiveness of adult seasonal flu vaccination Sponsors:   Harvard University;   Stanford University;   Massachusetts Institute of Technology Enrolling by invitation
Source: - Category: Research Source Type: clinical trials
Current challenges: from the path of "original antigenic sin" towards the development of universal flu vaccines. Int Rev Immunol. 2019 Nov 09;:1-16 Authors: Biswas A, Chakrabarti AK, Dutta S Abstract Annual flu led by influenza viruses is contemplated to be one of the foremost global health challenges due to its rapid spread leading to the life-threatening epidemic or pandemic. An enormous number of people die due to flu and its associated intricacies every year. Annual vaccination is considered to be the gold standard strategy to protect the individual from acquiring infection and further de...
Source: International Reviews of Immunology - Category: Allergy & Immunology Tags: Int Rev Immunol Source Type: research
A recent study in this journal reported the cross-species transmission of a novel swine H3N2 influenza A virus (IAV) to humans and suggested a heavy threat from the H3N2 IAVs (1). Vaccination remains the primary option for the control of influenza, but the protective efficiency of seasonal vaccines against H3N2 IAVs are suboptimal. Recent human H3N2 IAVs have shown poor growth in MDCK cells and eggs due to their low receptor binding affinities. A high yield strain is required for the vaccine manufacture, however, mutations of vaccine seeds during egg adaptation has reported to reduce the vaccine effectiveness (2).
Source: Journal of Infection - Category: Infectious Diseases Authors: Source Type: research
Current influenza vaccines manufactured using eggs have considerable limitations, both in terms of scale up production and the potential impact passaging through eggs can have on the antigenicity of the vaccine virus strains. Alternative methods of manufacture are required, particularly in the context of an emerging pandemic strain. Here we explore the production of recombinant influenza haemagglutinin using the ciliated protozoan Tetrahymena thermophila. For the first time we were able to produce haemagglutinin from both seasonal influenza A and B strains. This ciliate derived material was immunogenic, inducing an antibod...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
TUESDAY, Nov. 12, 2019 -- About one in three individuals with atherosclerotic cardiovascular disease (ASCVD) did not receive an influenza vaccination in the past year, according to a study presented at the annual meeting of the American Heart...
Source: - Pharma News - Category: Pharmaceuticals Source Type: news
Kinyoun Lecture Ian A. Wilson, D. Phil., D.Sc., Hansen professor of structural biology and chair, department of integrative structural and computational biology at The Scripps Research Institute, La Jolla, Calif., will deliver the 2019 Joseph J. Kinyoun Memorial Lecture on Tuesday, November 19, at 3 p.m. in Lipsett Amphitheater, Bldg. 10. His presentation is titled, “ Structure-assisted Design of Universal Vaccines and Therapeutics against Influenza Virus. ” Wilson will explain how insights gained through structural biology approaches are aiding in devising new ways to treat or prevent influenza. The health and...
Source: Videocast - All Events - Category: General Medicine Tags: Upcoming Events Source Type: video
AbstractPurpose of ReviewPregnant women and young infants are more likely to experience severe complications associated with influenza infection and are at increased risk of hospitalization. Influenza vaccination during pregnancy produces antibodies which protect the mother against infection, and due to transplacental transfer of maternal antibodies before birth, it also protects the infant in the first few months of life.Recent FindingsIn many countries, influenza vaccination is recommended during pregnancy to protect mothers and their infants. In fact, influenza vaccine is the most widely used vaccine in pregnancy global...
Source: Current Tropical Medicine Reports - Category: Tropical Medicine Source Type: research
Conclusions: The findings indicate that hospitalizations are associated with a significant increase in mortality in patients recently diagnosed with HF. It is important to reinforce the need for the prevention of acute decompensated HF and for strategies to improve post-discharge outcomes. PMID: 31702737 [PubMed - in process]
Source: Archivos de Cardiologia de Mexico - Category: Cardiology Authors: Tags: Arch Cardiol Mex Source Type: research
This study examines the associations of seasonal influenza severity as well as current and prior year ’s vaccine effectiveness with yearly influenza vaccination rates stratified by age groups.
Source: JAMA Pediatrics - Category: Pediatrics Source Type: research
This study presents the first evidence that the transcriptional regulator VjbR has important function in B. canis. In addition, according to its reduced virulence and the protective immunity it induces in mice, it can be a potential live attenuated vaccine against B. canis.
Source: Microbial Pathogenesis - Category: Infectious Diseases Source Type: research
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