Agile Development of a Digital Exposure Treatment for Youth With Chronic Musculoskeletal Pain

Conditions:   Chronic Pain;   Exposure;   Adolescent Behavior;   Child Behavior Intervention:   Behavioral: Graded exposure treatment (GET) Sponsors:   Stanford University;   Karolinska Institutet;   National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) Not yet recruiting
Source: - Category: Research Source Type: clinical trials

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Exp Mol Med. 2021 Nov 30. doi: 10.1038/s12276-021-00710-y. Online ahead of print.ABSTRACTOsteoarthritis (OA) is the most common form of arthritis. It is characterized by progressive destruction of articular cartilage and the development of chronic pain and constitutes a considerable socioeconomic burden. Currently, pharmacological treatments mostly aim to relieve the OA symptoms associated with inflammation and pain. However, with increasing understanding of OA pathology, several potential therapeutic targets have been identified, enabling the development of disease-modifying OA drugs (DMOADs). By targeting inflammatory cy...
Source: Molecular Medicine - Category: Molecular Biology Authors: Source Type: research
This holiday season, we are all in search of the perfect gift. What is the one thing you truly desire for yourself and your family? Don’t you think we all want it? What if you were handed a beautifully wrapped box containing a miraculous tool that caused dramatic weight loss and good health without limiting calories or requiring exercise? What if this gift reduced appetite, shrunk belly fat, and dropped your dress size? What if that same gift freed you from acid reflux, heartburn, bowel urgency, and diarrhea, but also improved mood, increased energy, deepened sleep, and reduced or eliminated joint pain? And all of th...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: Open Source Type: blogs
Yoo Yoon Kim Septic ankle arthritis is a devastating clinical entity with high risks of morbidity and mortality. Prompt treatment is necessary because delayed or inadequate treatment can lead to irreversible damage that may occur on the articular surface, resulting in cartilage erosion, infective synovitis, osteomyelitis, joint deformity, and pain and joint dysfunction. An aggressive surgical approach is required when a joint infection causes severe limb-threatening arthritis. A 58-year-old woman visited our clinic with increasing pain in the right ankle, which had been present for the previous 2 months. She ...
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Case Report Source Type: research
ARTHRITIS causes inflammation of joints and consequently leads to pain. This pain can get worse during the winter months as the temperatures drop. New research has found that general chronic pain affects more than four in 10 people. Here, few experts provide advice on how to ease joint pain becoming worse during winter as well as what to avoid.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
This study aims to investigate chronic widespread pain with the 1990 (CWP1990) and 2019 (CWP2019) definitions 6 years after the onset of rheumatoid arthritis (RA), in one patient cohort with tight controls and one conventional cohort, and factors associated with reporting CWP1990 and CWP2019, respectively.METHODS: A cohort of 80 RA patients with monthly visits to the physician the first 6 months was compared to a cohort of 101 patients from the same clinic with conventional follow-up. Both cohorts had early RA (
Source: Pain Physician - Category: Anesthesiology Authors: Source Type: research
OSTEOMYELITIS IN CHILDREN: Osteomyelitis (OM) is defined as an infection of the bone marrow and adjacent osseous structures with potential surrounding soft tissue extent. It can occur at any age, generally in children 1 –16 years old. In children, it is predominantly caused by hematogenous spread of infection, typically bacterial. Generally, the metaphysis is involved. Transphyseal spread to the epiphysis and joint is rare but can occur in children younger than 18 months, or in older children with closed growth p lates, due to a different blood perfusion to the epiphysis. The first imaging modality of choice is conve...
Source: Journal of the Belgian Society of Radiology - Category: Radiology Source Type: research
SPRING HOUSE, PENNSYLVANIA, November 17, 2021 – The Janssen Pharmaceutical Companies of Johnson &Johnson today announced topline results from the Phase 2 GALAXI 1 clinical trial which showed rates of clinical remission (Crohn’s Disease Activity Index [CDAI]
Source: Johnson and Johnson - Category: Pharmaceuticals Source Type: news
Proximal row carpectomy (PRC) is a long-time, well-accepted, easy-to-reproduce procedure for the treatment of several painful degenerative conditions of the wrist, when capitate pole and radius lunate fossa are preserved. It has been reported to relieve pain and preserve a substantial wrist range of motion, although a partial loss of strength has to be expected because of the decreased length of the carpus. Since 2010, a new technique has been described in the literature using the resurfacing capitate pyrocarbon implant, combined with PRC. This implant has been designed to perform PRC even in the presence of degenerate joi...
Source: Techniques in Hand and Upper Extremity Surgery - Category: Surgery Tags: Techniques Source Type: research
Orthop Rev (Pavia). 2021 Jul 10;13(2):25549. doi: 10.52965/001c.25549. eCollection 2021.ABSTRACTPURPOSE OF REVIEW: The purpose of this systematic review is to discuss emerging evidence in the field of viscosupplementation for chronic knee pain secondary to Osteoarthritis (OA). This review focuses on types of viscosupplementation that are clinically available currently, evidence to support their use, contraindications, and adverse events.RECENT FINDINGS: OA, also known as degenerative joint disease, is the most common form of arthritis in the United States, affecting 54.4 million, or 22.7% of the adult population. The knee ...
Source: Pain Physician - Category: Anesthesiology Authors: Source Type: research
Arthritis is the most common cause to lead to chronic pain. Botulinum toxin type A (BoNT/A) has been widely used to treat chronic pain. In our previous study, we confirmed the anti-inflammatory and antinociceptive effects of BoNT/A in the Complete Freund’s Adjuvant (CFA)-induced arthritis model, but the underlying anti-inflammatory mechanism was not fully elucidated. The purpose of this study was to investigate the anti-inflammatory effects and mechanisms of BoNT/A on arthritis using transcriptomic analysis. The BoNT/A was injected into the rat ankle joint on day 21 after CFA injection. The von Frey and hot plate tes...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
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