Thymidylate synthase locus LOH in combination with genotype has prognostic and predictive significance in colorectal cancer

In conclusion, LOH status should be considered when TS genotype is explored as a potential prognostic and predictive marker for 5-FU-based adjuvant chemotherapy in colorectal cancer.PMID:34650802 | PMC:PMC8506693 | DOI:10.3892/mco.2021.2398

Source: Clinical Colorectal Cancer - October 15, 2021 Category: Cancer & Oncology Authors: Masanori Kotake Hiroyuki Bando Mami Kaneko Hirofumi Takemura Toshinari Minamoto Kazuyuki Kawakami Source Type: research