Forestalling age-impaired angiogenesis and blood flow by targeting NOX: Interplay of NOX1, IL-6, and SASP in propagating cell senescence [Medical Sciences]

In an aging population, intense interest has shifted toward prolonging health span. Mounting evidence suggests that cellular reactive species are propagators of cell damage, inflammation, and cellular senescence. Thus, such species have emerged as putative provocateurs and targets for senolysis, and a clearer understanding of their molecular origin and regulation...

Source: Proceedings of the National Academy of Sciences - October 15, 2021 Category: Science Authors: Yao Li, Damir Kračun, Christopher M. Dustin, Mohamed El Massry, Shuai Yuan, Christian J. Goossen, Evan R. DeVallance, Sanghamitra Sahoo, Cynthia St. Hilaire, Aditi U. Gurkar, Toren Finkel, Adam C. Straub, Eugenia Cifuentes–Pagano, Patrick J. Tags: Medical Sciences Biological Sciences Source Type: research