Vitamin D and Painful Diabetic Neuropathy

Condition:   Painful Diabetic Neuropathy Intervention:   Drug: Cholecalciferol Sponsor:   Baqai Institute of Diabetology and Endocrinology Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials

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Today's materials from the Intraclear Biologics team may be of interest to those following the development of senolytic therapies. Since the Mayo Clinic has yet to publish results from their clinical trials of fisetin as a senolytic therapy, and may not do so for a few years yet, it is good to see even preliminary data from other sources. Senolytic therapies selectively destroy senescent cells, though only one approach (the combination of dasatinib and quercetin) has been definitely shown to destroy significant numbers of senescent cells in humans. Data has yet to be published on whether fisetin performs as well in humans ...
Source: Fight Aging! - Category: Research Authors: Tags: Self-Experimentation Source Type: blogs
The antibiotic-free formulation shows potential as a targeted treatment for antimicrobial-resistant bacteria in chronic wounds such as diabetic foot ulcers, as well as a potential therapy for SARS-CoV-2.Medscape Medical News
Source: Medscape Dermatology Headlines - Category: Dermatology Tags: Infectious Diseases News Source Type: news
Parathyroidectomy is associated with a lower risk of fracture compared with nonsurgical management among older adults with primary hyperparathyroidism, a new study indicates.Reuters Health Information
Source: Medscape Orthopaedics Headlines - Category: Orthopaedics Tags: Diabetes & Endocrinology News Source Type: news
Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy - Category: Endocrinology Tags: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy Source Type: research
Consanguineous families have often played a role in the discovery of novel genes, especially in paediatric endocrinology. At this time, it has been estimated that over 8.5% of all children worldwide have consanguineous parents. Consanguinity is linked to demographic, cultural and religious practises and is more common in some areas around the world than others. In children with endocrine conditions from consanguineous families, there is a greater probability that a single gene condition with autosomal recessive inheritance is causative. From 1966 and the first description of Laron syndrome, through the discovery of the f...
Source: Hormone Research in Paediatrics - Category: Endocrinology Source Type: research
SAN DIEGO, Nov. 30, 2021 -- (Healthcare Sales &Marketing Network) -- ViaCyte, Inc., a clinical-stage regenerative medicine company developing novel cell replacement therapies to address diseases with significant unmet needs, today announced the appointme... Regenerative Medicine, Personnel ViaCyte, cell therapy, diabetes
Source: HSMN NewsFeed - Category: Pharmaceuticals Source Type: news
Source: Current Pharmacogenomics and Personalized Medicine - Category: Genetics & Stem Cells Source Type: research
AbstractDiabetic kidney disease (DKD) is a highly prevalent complication of Diabetes Mellitus (DM) and the leading cause of end-stage kidney disease (ESKD). Inflammation is recognized as an important driver of progression of DKD. Activation of the immune response promotes a pro-inflammatory milieu and subsequently renal fibrosis and a progressive loss of renal function. While the role of the innate immune system in diabetic renal disease has been well characterised, the potential contribution of the adaptive immune system remains poorly defined. Emerging evidence in experimental models of DKD indicates an increase in the n...
Source: Journal of Diabetes Investigation - Category: Endocrinology Authors: Tags: REVIEW ARTICLE Source Type: research
Condition:   Diabetic Retinopathy Interventions:   Drug: Ranibizumab Injection [Lucentis];   Procedure: Inner limiting membrane stripping;   Drug: Dexamethasone intravitreal implant Sponsor:   Affiliated Hospital of Nantong University Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Trends Immunol. 2021 Nov 27:S1471-4906(21)00238-6. doi: 10.1016/j.it.2021.11.002. Online ahead of print.ABSTRACTCatestatin (CST) is a bioactive cleavage product of the neuroendocrine prohormone chromogranin A (CgA). Recent findings show that CST can exert anti-inflammatory and antiadrenergic effects by suppressing the inflammatory actions of mammalian macrophages. However, recent findings also suggest that macrophages themselves are major CST producers. Here, we hypothesize that macrophages produce CST in an inflammation-dependent manner and thereby might self-regulate inflammation in an autocrine fashion. CST is associate...
Source: Trends in Immunology - Category: Allergy & Immunology Authors: Source Type: research
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