OPSYNVI ® (macitentan and tadalafil) Becomes the First and Only Health Canada-Approved Once Daily Fixed Dose Combination Treatment for Patients with Pulmonary Arterial Hypertension (PAH)

Toronto, ON, (October 15, 2021) – The Janssen Pharmaceutical Companies of Johnson & Johnson announced today that Health Canada approved OPSYNVI® (macitentan 10mg and tadalafil 40mg) for the long-term treatment of pulmonary arterial hypertension (PAH, World Health Organization [WHO] Group 1) to reduce morbidity in patients of WHO functional class (FC) II or III whose PAH is idiopathic, heritable, or associated with connective tissue disease or congenital heart disease.OPSYNVI® should be used in patients who are currently treated concomitantly with stable doses of macitentan 10mg and tadalafil 40mg (20mg x 2) as separate tablets.PAH is a specific, rare form of pulmonary hypertension (PH) that affects the right side of the heart and causes the walls of the pulmonary arteries (blood vessels leading from the right side of the heart to the lungs) to become thick and stiff, narrowing the space for blood to flow, and causing increased blood pressure to develop within the lungs. If left untreated, PH can lead to right ventricle failure, a serious type of heart failure.[1]“PAH is a progressive disease that can affect people of any age or ethnic background. While there is no cure, there have been considerable advancements in care and we now have a gold standard option to improve pulmonary vascular resistance, lessen disease morbidity and reduce right heart impact,” said Dr. Lisa Mielniczuk, Director of the Pulmonary Hypertension Program at the Ottawa Heart Institute and Co-V...
Source: Johnson and Johnson - Category: Pharmaceuticals Tags: Innovation Source Type: news