Impact of socio-demographic and clinical characteristics on functional disability and health-related quality of life in patients with rheumatoid arthritis: a cross-sectional study from Palestine

Rheumatoid arthritis (RA) is a chronic autoimmune disorder, which has a significant impact on patients' health-related quality of life (HRQoL), and limits physical function as well as increases pain and fatigu...
Source: Health and Quality of Life Outcomes - Category: International Medicine & Public Health Authors: Tags: Research Source Type: research

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SPRING HOUSE, PENNSYLVANIA, December 3, 2021 – The Janssen Pharmaceutical Companies of Johnson &Johnson today announced new TREMFYA® (guselkumab) efficacy and safety data from the Phase 3b COSMOS trial published in Annals of the Rheumatic Diseases (ARD), evaluating this selective interleukin (IL)-23 inhibitor in adults with active psoriatic arthritis (PsA) who demonstrated inadequate efficacy or intolerance to tumor necrosis factor inhibition (TNFi).1 Results showed significantly higher proportions of patients treated with TREMFYA had improvement in joint signs and symptoms and complete skin clearance versus ...
Source: Johnson and Johnson - Category: Pharmaceuticals Tags: Innovation Source Type: news
AbstractPain and inflammatory disorders are significant health problems because of prevalence and associated disabilities. In this context, LASSBio-596 is a hybrid compound able to modulate TNF- α and phosphodiesterases 4 and 5, exhibiting an anti-inflammatory effect in the pulmonary inflammatory model. Aiming at a better description of the activities of LASSBio-596, we initially conducted nociception tests (acetic acid-induced abdominal writhing, glutamate, and formalin-induced nociceptio n and hot plate test) and later inflammatory tests (acute, peritonitis; and chronic, arthritis) that directed us to this last one...
Source: Inflammation - Category: Allergy & Immunology Source Type: research
Every few years someone, somewhere, announces that “it won’t be long before we have a treatment to rid the world of persistent pain.” And there’s a hiss and roar to celebrate this momentous finding, and much ado about how wonderful it will be. I’m still waiting. BUT I thought it might be an interesting thought experiment to wonder what might happen if a “cure” was available for fibromyalgia. As readers will know, I have lived with what eventually was named “fibromyalgia” since my early 20’s, and probably longer. I’ve dabbled in various treatments ove...
Source: HealthSkills Weblog - Category: Anesthesiology Authors: Tags: Chronic pain Pain conditions Professional topics Research Science in practice biopsychosocial pain management Therapeutic approaches Source Type: blogs
Conclusions: The majority of RA patients had favourable outcomes and low costs. However, a large group of patients was distinguished by chronic pain, disability, and fatigue not unambiguously linked to disease activity. The highest healthcare costs were linked to high disease activity or comorbidities.PMID:34511040 | DOI:10.1080/03009742.2021.1944306
Source: Scandinavian Journal of Rheumatology - Category: Rheumatology Authors: Source Type: research
Conclusion: There are modifiable factors associated with transitions from and to CWP that could be identified. Paying attention to these factors could improve pain treatment in the management of RA.PMID:34470572 | DOI:10.1080/03009742.2021.1944304
Source: Scandinavian Journal of Rheumatology - Category: Rheumatology Authors: Source Type: research
Conclusion The use of an ulnar deviation orthosis by patients with RA could reduce hand pain, improve grip strength, and promote upper-limb function.
Source: JPO Journal of Prosthetics and Orthotics - Category: Orthopaedics Tags: ORIGINAL RESEARCH ARTICLES Source Type: research
In conclusion, these results suggested that nuclear membrane-targeted AuNSs effectively attenuated arthritis progression without systemic side effects.PMID:34060659 | DOI:10.1111/1440-1681.13531
Source: Clinical and Experimental Pharmacology and Physiology - Category: Drugs & Pharmacology Authors: Source Type: research
More News: Arthritis | Chronic Pain | Disability | International Medicine & Public Health | Middle East Health | Pain | Palestine Health | Rheumatoid Arthritis | Rheumatology | Study