Cancers, Vol. 13, Pages 5144: Brain and Breast Cancer Cells with PTEN Loss of Function Reveal Enhanced Durotaxis and RHOB Dependent Amoeboid Migration Utilizing 3D Scaffolds and Aligned Microfiber Tracts

Conclusions: This study demonstrates a significant role of the PTEN genotype and RHOB expression for durotaxis, adhesion and migration dependent on 3D. GBM and TNBC cells with PTEN loss of function have an affinity for stiff brain structures promoting metastasis. 3D microfibers represent an important tool to model brain metastasizing tumor cells, where RHO-inhibitors could play an essential role for improved therapy.

Source: Cancers - October 14, 2021 Category: Cancer & Oncology Authors: Annalena Wieland Pamela L. Strissel Hannah Schorle Ezgi Bakirci Dieter Janzen Matthias W. Beckmann Markus Eckstein Paul D. Dalton Reiner Strick Tags: Article Source Type: research