Short-Chain Fatty Acids Calibrate RAR α Activity Regulating Food Sensitization

Gut-microbiota dysbiosis links to allergic diseases. The mechanism of the exacerbation of food allergy caused by gut-microbiota dysbiosis remains unknown. Regulation of retinoic acid receptor alpha (RARα) signaling is critical for gut immune homeostasis. Here we clarified that RARα in dendritic cells (DCs) promotes Th2 cell differentiation. Antibiotics treatment stimulates retinoic acid signaling in mucosal DCs. We found microbiota metabolites short-chain fatty acids (SCFAs) maintain IGF-1 levels in serum and mesenteric lymph nodes. The IGF-1/Akt pathway is essential for regulating the transcription of genes targeted by RARα. And RARα in DCs affects type I interferon (IFN-I) responses through regulating transcription of IFN-α. Our study identifies SCFAs crosstalk with RARα in dendritic cells as a critical modulator that plays a core role in promoting Th2 cells differentiation at a state of modified/disturbed microbiome.
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research

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Medicina (Kaunas). 2021 Nov 14;57(11):1245. doi: 10.3390/medicina57111245.ABSTRACTThe diagnosis of food intolerance is tricky due to the different etiologies of adverse reactions. There is also a lack of clear rules for interpreting alternative tests used to diagnose these problems. The analyses of IgG4 concentration in serum or cytotoxic tests became the basis of elimination diets. However, it can result in nutritional deficiencies and loss of tolerance to eliminated foods. Our study aimed to assess the necessity of food elimination in four cases with food intolerance symptoms based on alternative diagnostic tests. Four p...
Source: Medicina (Kaunas) - Category: Universities & Medical Training Authors: Source Type: research
J Investig Allergol Clin Immunol. 2021 Nov 26:0. doi: 10.18176/jiaci.0768. Online ahead of print.ABSTRACTBACKGROUND: Atopic manifestations are describedas clinical feature of variousprimary immunodeficiency disease (PID) phenotypes and in particular frequently reported in the combined immune deficiencies. The prevalence of atopic manifestations in other PIDs remains largely unknown.OBJECTIVE: To evaluate the prevalence of atopic manifestations in other PIDs and to identify in which PIDsatopic manifestations are most common in order to improve patient care.METHODS: A partner-controlled questionnaire-based study was performe...
Source: Journal of Investigational Allergology and Clinical Immunology - Category: Allergy & Immunology Authors: Source Type: research
Conclusions: Our findings lend further support to the notion of early childhood as a critical period when allergy may be programmed via the gut microbiota. Higher levels of fecal valeric acid may be characteristic of a protective gut microbiota and/or actively contribute to protection from eczema and food allergy.Int Arch Allergy Immunol
Source: International Archives of Allergy and Immunology - Category: Allergy & Immunology Source Type: research
The pathophysiology of childhood food allergy (FA) and its natural history are poorly understood. Clarification of the underlying mechanism may aid in identifying novel biomarkers and strategies for clinical intervention in children with FA.
Source: Journal of Allergy and Clinical Immunology - Category: Allergy & Immunology Authors: Source Type: research
Am J Nurs. 2021 Aug 1;121(8):12-13. doi: 10.1097/01.NAJ.0000767740.76705.23.ABSTRACTAmong controversial new recommendations: doing away with categorical food bans.PMID:34819456 | DOI:10.1097/01.NAJ.0000767740.76705.23
Source: The American Journal of Nursing - Category: Nursing Source Type: research
Early life asthma phenotyping remains an unmet need in pediatric asthma; necessary to overcome the underdiagnoses and increased morbidity in childhood.  Phenotyping of asthma in France has been exclusively focused on severe pediatric asthma, and till date phenotypes of childhood asthma in the general population have not been ascertained. We aimed to determine wheezing profiles and asthma phenotypes in preschool children in French general population.Symptoms were determined using parental responses to modified versions of ISAAC questionnaire from 2 months to age 5. Supervised wheeze clusters were determined exclusively...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Epidemiology Source Type: research
Aim: Accurately diagnosing asthma can be challenging. We aimed to derive and internally validate a prediction model to support primary care clinicians assess the probability of an asthma diagnosis in children and young people with symptoms suggestive of asthma.Methods: We created a dataset from the Avon Longitudinal Study of Parents and Children (ALSPAC) enhanced with data from electronic health records. Participants with at least 3 inhaled steroid prescriptions in 12 months and a coded asthma diagnosis were designated as having asthma. Potential candidate predictors were included if data were available in at least 60% of ...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: General practice and primary care Source Type: research
This study aims to identify phenotypes in asthmatic children using the gut microbial profiles.Methods: Clinical data, lung function, blood and faeces samples were collected from the Systems Pharmacology approach to uncontrolled Pediatric Asthma (SysPharmPediA) study including moderate-to-severe asthmatics aged 6-18 years and treated on GINA step ≥3. Gut microbiome 16S rRNA sequencing was performed and a clustering strategy was applied as described previously (Abdel-Aziz et al. JACI 2021; 147(1):123-34).Results: Cluster-based gut microbiome analysis of 103 asthmatic children (median age: 11.5 years, 64% male) revealed tw...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Paediatric asthma and allergy Source Type: research
Peanut allergy is a common food allergy and the main cause of anaphylaxis among children. Peanut oral immunotherapy (pOIT) can lead to desensitization, and combined treatment with omalizumab may facilitate OIT initiation. Still, mechanisms of tolerance are not well understood. We therefore investigated transcriptional changes using RNA-seq profiles during omalizumab treatment and pOIT.Peanut-allergic adolescents (n=17, age 12-19 years) were included and treated with omalizumab for 8 weeks followed by a step-wise increase of daily peanut ingestion, and subsequent withdrawal of omalizumab. Finally, an open peanut challenge w...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Paediatric asthma and allergy Source Type: research
Background: Asthma, rhinitis and eczema often coexist, especially if there is a history of allergy. Little is known regarding the relation between allergic multimorbidity and the degree of type-2 inflammation.Objective: To investigate subjects with allergic multimorbidity in terms of type-2 markers, immunoglobulin E (IgE) sensitization, respiratory and food allergy symptoms.Methods: A total of 411 children and young adults with physician-diagnosed asthma were tested for exhaled nitric oxide (FENO), total and specific IgE, plasma eosinophil-derived neurotoxin (P-EDN) and blood eosinophils (B-Eos). Respiratory and allergy sy...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Paediatric asthma and allergy Source Type: research
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