Breast cancer: Women’s cycle length during menopause transition increases risk says study

BREAST cancer is the most common cancer among women. A new study warns a women's cycle length in the build up to the menopause impacts oestrogen which could further impact risk of developing the deadly disease.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news

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Clin Obstet Gynecol. 2021 Sep 29. doi: 10.1097/GRF.0000000000000657. Online ahead of print.ABSTRACTProgestogens are steroid compounds that have the ability to induce secretory transformation in the endometrium and are utilized in menopausal hormone therapy to prevent endometrial hyperplasia and endometrial cancer. Progestogens can be derived from 21-carbon or 19-carbon steroid cytoskeletons and thus have different properties and metabolic effects beyond the progestational effects on the endometrium. This limited review will focus on the available progestogens utilized in combination hormone therapy including progesterone, ...
Source: Clinical Breast Cancer - Category: Cancer & Oncology Authors: Source Type: research
No abstract available
Source: Menopause - Category: OBGYN Tags: Editorials Source Type: research
Conclusions: Women with earlier age at menopause, and ER+ and/or PR+ stage I-III breast cancer were more likely to develop metastatic breast cancer. Age increased the risk of metastatic relapse for women with ER− and PR− disease, but not for ER+ and/or PR+ cancers.
Source: Menopause - Category: OBGYN Tags: Original Studies Source Type: research
AbstractAimTo explore the effect of TEC chemotherapy regimen (Docetaxel  + Epirubicin + Cyclophosphamide) on traditional cardiovascular risk factors, atherosclerotic cardiovascular disease and cardiac electrical activity.Design243 patients with first initially diagnosed breast cancer were collected who receiving TEC chemotherapy.MethodsUnivariate analysis, multivariate analysis, binary logistic regression analysis and statistical description were used to analyse the data.ResultsAmong the first diagnosed patients, prevalence of hypertension and overweight/obesity in postmenopausal patients were significa...
Source: Nursing Open - Category: Nursing Authors: Tags: RESEARCH ARTICLE Source Type: research
In conclusion, although survival did not differ significantly, more NCT patients might able to avoid ALND, with fewer LNs removed with lower LN positivity.Clinical Trial Registrationhttps://clinicaltrials.gov/ct2/show/NCT01622361, identifier NCT01622361.
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
Reproductive ageing leading to menopause is characterized by depletion of follicles and its regulating mechanisms are only partly understood. Early age at menopause and premature ovarian insufficiency (POI) are associated with several other traits such as cardiovascular disease, dyslipidemia, osteoporosis and diabetes. In large cohorts of Northern European women hundreds of Single Nucleotide Polymorphisms (SNPs) have been identified to be associated with age at menopause. These SNPs are located in genes enriched for immune and mitochondrial function as well as DNA repair and maintenance processes. Genetic predisposition to...
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research
J Clin Med. 2021 Sep 16;10(18):4192. doi: 10.3390/jcm10184192.ABSTRACTA significant number of women receive a cancer diagnosis before their age of natural menopause. Among these patients, the most frequent neoplasms are breast cancer, gynecological, and hematological malignancies. Premature ovarian insufficiency and infertility are among the most feared short- to long-term consequences of anticancer treatments in premenopausal patients. Both patient- and treatment-related characteristics are key factors in influencing the risk of gonadotoxicity with the use of chemotherapy. The cryopreservation of oocytes/embryos is a stan...
Source: Clinical Breast Cancer - Category: Cancer & Oncology Authors: Source Type: research
Ann Ital Chir. 2021 Aug 20;10:S0003469X21035053. Online ahead of print.ABSTRACTAIM: The impact of COVID-19 pandemic is pronounced in each healthcare process, including the management of breast cancer. The anxiety of COVID-19 changes patient preferences and some delay in routine controls and surgical managements occur. Some disintegration in medical care is to be expected during the pandemic, but the new coping strategies are needed in order to avoid delayed diagnosis of breast cancer.METHODS: A total number of 140 patients assigned for biopsy and diagnosed with breast cancer in our tertiary clinic between December 1st and ...
Source: Annali Italiani di Chirurgia - Category: Surgery Authors: Source Type: research
CONCLUSIONS: In women who harbour a pathogenic or likely pathogenic variant in BRCA1 and BRCA2 screening for ovarian cancer is not recommended. Risk-reducing surgery is recommended to reduce the risk of ovarian cancer. In the absence of contraindications, premenopausal women undergoing RRSO should be offered hormone therapy until menopause. Systemic hormone replacement therapy, is not recommended for women who have had a personal history of breast cancer. RRSO should be considered for breast cancer risk reduction in women younger than 50 years. After a breast cancer diagnosis, RRSO for breast cancer mortality reduction can...
Source: Clinical Breast Cancer - Category: Cancer & Oncology Authors: Source Type: research
Ann Ital Chir. 2021 Aug 20;10:S0003469X21035053. Online ahead of print.ABSTRACTAIM: The impact of COVID-19 pandemic is pronounced in each healthcare process, including the management of breast cancer. The anxiety of COVID-19 changes patient preferences and some delay in routine controls and surgical managements occur. Some disintegration in medical care is to be expected during the pandemic, but the new coping strategies are needed in order to avoid delayed diagnosis of breast cancer.METHODS: A total number of 140 patients assigned for biopsy and diagnosed with breast cancer in our tertiary clinic between December 1st and ...
Source: Annali Italiani di Chirurgia - Category: Surgery Authors: Source Type: research
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