Immunomodulation of endothelial cells induced by macrolide therapy in a model of septic stimulation

ConclusionThis study reports phenotypic and gene expression changes in septic-stimulated ECs exposed to macrolides, without resulting in altered immunogenicity of ECs in co-cultures with PBMCs. In vivo studies may help to further understand the impact of macrolide therapy on ECs immune homeostasis during sepsis.

Source: Immunity, Inflammation and Disease - October 12, 2021 Category: Allergy & Immunology Authors: St éphanie Pons, Eden Arrii, Marine Arnaud, Maud Loiselle, Juliette Ferry, Manel Nouacer, Julien Lion, Shannon Cohen, Nuala Mooney, Lara Zafrani Tags: ORIGINAL ARTICLE Source Type: research