Integration of pairwise neighbor topologies and miRNA family and cluster attributes for miRNA-disease association prediction

We present a disease-related miRNA prediction method by encoding and integrating multiple representations of miRNA and disease nodes learnt from the generative and adversarial perspective. We firstly construct a bilayer heterogeneous network of miRNA and disease nodes, and it contains multiple types of connections among these nodes, which reflect neighbor topology of miRNA-disease pairs, and the attributes of miRNA nodes, especially miRNA-related families and clusters. To learn enhanced pairwise neighbor topology, we propose a generative and adversarial model with a convolutional autoencoder-based generator to encode the low-dimensional topological representation of the miRNA-disease pair and multi-layer convolutional neural network-based discriminator to discriminate between the true and false neighbor topology embeddings. Besides, we design a novel feature category-level attention mechanism to learn the various importance of different features for final adaptive fusion and prediction. Comparison results with five miRNA-disease association methods demonstrated the superior performance of our model and technical contributions in terms of area under the receiver operating characteristic curve and area under the precision-recall curve. The results of recall rates confirmed that our model can find more actual miRNA-disease associations among top-ranked candidates. Case studies on three cancers further proved the ability to detect potential candidate miRNAs.PMID:34634106 | DOI:10...

Source: Briefings in Bioinformatics - October 11, 2021 Category: Bioinformatics Authors: Ping Xuan Dong Wang Hui Cui Tiangang Zhang Toshiya Nakaguchi Source Type: research