Juzentaihoto Exerts Anti-Allergic Effects by Inhibiting Effector T-Cell Activation and Inducing and/or Activating Regulatory T Cells in a Murine Model of Contact Hypersensitivity
Conclusion: We suggested that JTT exerts anti-allergic effects by regulating the activation of effector T cells and Tregs involved in murine CHS model.Int Arch Allergy Immunol
CONCLUSION: The numerous biologic options have made the selection of the best biologic for each patient a potential conundrum for clinicians. Adequate point of care biomarkers to facilitate personalized medical therapy are generally lacking. Furthermore, although clinically effective and generally safe, none of the biologics discussed in this review have induced long-standing disease remission. Nevertheless, these agents have given us the opportunity to treat the most severe patients and to better understand the biology of respiratory and allergic diseases. As knowledgeable physicians, we should embrace and be educated on ...
Stem Cell Res Ther. 2021 Oct 11;12(1):539. doi: 10.1186/s13287-021-02583-4.ABSTRACTAllergic diseases are immune-mediated diseases. Allergies share a common immunopathogenesis, with specific differences according to the specific disease. Mesenchymal stem/stromal cells (MSCs) have been applied to people suffering from allergic and many other diseases. In this review, the immunologic roles of MSCs are systemically reviewed according to disease immunopathogenesis from a clinical viewpoint. MSCs seem to be a promising therapeutic modality not only as symptomatic treatments but also as causative and even preventive treatments fo...
People with asthma, atopic dermatitis and hay fever may be more likely to suffer from depression, anxiety, bipolar disorder and other mental health disorders, a study published by Clinical and Experimental Allergy found.
Allergic diseases such as asthma, atopic dermatitis and hay fever do not cause the onset of mental health conditions or vice versa, according to the findings of a new University of Bristol-led study published today (6 October) in the journal Clinical and Experimental Allergy.
Volume 32, Issue 1, December 2021, Page 625-649 .
Atopic dermatitis is a complex, chronic inflammatory skin disorder with significant morbidity. It is often a frustrating condition for both children and parents due to chronic and relapsing course. There is now an increasing understanding of the disease pathogenesis resulting in discovery of much wanted newer therapeutics and targeted therapies after a long time. Whether these interventions will result in sustained benefits or long term cure remains to be seen.
Asthma is an inflammatory disease of the airways characterized by intermittent episodes of wheezing, chest tightness, and cough. Many of the inflammatory pathways implicated in asthma involve cytokines and growth factors that activate Janus kinases (JAKs). The discovery of the JAK/signal transducer and activator of transcription (STAT) signaling pathway was a major breakthrough that revolutionized our understanding of cell growth and differentiation. JAK inhibitors are under active investigation for immune and inflammatory diseases, and they have demonstrated clinical efficacy in diseases such as rheumatoid arthritis and atopic dermatitis.
With regard to the article in the December 2019 issue entitled "Phase 2 clinical study of delgocitinib ointment in pediatric patients with atopic dermatitis" (J Allergy Clin Immunol 2019;144:1575-83), the authors report an error in an author ’s degree. Takeshi Nagata's degree should be BS, not MS.
ConclusionSES is a proxy measure for lifestyle features and characteristics including dietary habits, allergen exposure and other environmental factors and it is an important risk factor for atopic dermatitis, rhinitis and food allergy.
Evaluation of psychiatric morbidity in atopic dermatitis (AD) patients is essential for comprehensive care. AD is known to be associated with multiple mental disorders. Until now, a possible association between AD and eating disorders has remained unknown. We aimed to investigate the relationship between AD, eating disorders (ED) and food allergies. This retrospective epidemiological Finnish hospital registry-based study was conducted by identifying all cases of AD under the age of 18 at the time of diagnosis between 1987 and 2018.