Association of Sofosbuvir and Daclatasvir Plasma Trough Concentrations with Patient-, Treatment-, and Disease-Related Factors Among HIV/HCV-Coinfected Persons

ConclusionsIn HIV/HCV-coinfected patients in a real-world setting, exposure to a high GS-331007 Ctrough was associated with a slight decrease in renal function, while advanced hepatic impairment was significantly associated with a lower daclatasvir Ctrough. Though the clinical and therapeutic relevance of these findings may be limited, increasing clinicians ’ knowledge regarding DAA exposure in difficult-to-treat patients could be relevant in single cases, and further investigations are warranted.
Source: European Journal of Drug Metabolism and Pharmacokinetics - Category: Drugs & Pharmacology Source Type: research

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Postacute COVID syndrome, an ongoing inflammatory state following infection with SARS-CoV-2, is associated with greater risk of metabolic-associated fatty liver disease.Medscape Medical News
Source: Medscape Gastroenterology Headlines - Category: Gastroenterology Tags: Infectious Diseases News Source Type: news
ConclusionOur data emphasize that metabolic dysfunction has a significant impact on hepatocarcinogenesis in patients with NAFLD. Moreover, coexisting multiple metabolic risk factors would dampen the risk of developing HCC in patients with NAFLD. Closely tracing HCC formation through laboratory examination or imaging is crucial in these patients.
Source: Hepatology International - Category: Infectious Diseases Source Type: research
Bariatric surgery is often the treatment of last resort, but considering it earlier may be just what patients with fatty liver disease need.Medscape Gastroenterology
Source: Medscape General Surgery Headlines - Category: Surgery Tags: Gastroenterology Commentary Source Type: news
This study aims to develop an organoid-based 3D culture model to recapitulate key features of fatty liver disease focusing on intracellular lipid accumulation and metabolic dysregulation. We used human liver-derived intrahepatic cholangiocyte organoids and hepatocyte differentiated organoids. These organoids were exposed to lactate, pyruvate, and octanoic acid (LPO) for inducing lipid accumulation and mitochondrial impairment. Lipid accumulation resulted in alternations of gene transcription with major effects on metabolic pathways, including triglyceride and glucose level increase, which is consistent with metabolic chang...
Source: Molecular Medicine - Category: Molecular Biology Authors: Source Type: research
Expert Rev Gastroenterol Hepatol. 2022 Jan 20. doi: 10.1080/17474124.2022.2032661. Online ahead of print.ABSTRACTINTRODUCTION: Non-alcoholic fatty liver disease is a common liver disease with a global average prevalence of about 25%. In addition to the incidence of NAFLD being related to obesity, diabetes, hyperlipidemia, etc., genetic factors also have an important impact on the incidence of NAFLD.AREAS COVERED: Current experimental results and clinical studies show that the transmembrane 6 superfamily member 2 (TM6SF2) gene plays an important role in the pathogenesis of NAFLD. The research on genetic polymorphism of TM6S...
Source: Expert Review of Gastroenterology and Hepatology - Category: Gastroenterology Authors: Source Type: research
Assessing the risk for specific patient groups to suffer from severe courses of COVID-19 is of major importance in the current SARS-CoV-2 pandemic. This review focusses on the risk for specific patient groups with chronic respiratory conditions, such as patients with asthma, chronic obstructive pulmonary disease, cystic fibrosis (CF), sarcoidosis, interstitial lung diseases, lung cancer, sleep apnea, tuberculosis, neuromuscular diseases, a history of pulmonary embolism, and patients with lung transplants. Evidence and recommendations are detailed in exemplary cases. While some patient groups with chronic respiratory condit...
Source: Respiration - Category: Respiratory Medicine Source Type: research
As a biomarker for liver disease, bilirubin has been utilized in prognostic scoring systems for cirrhosis. While laboratory-based methods are used to determine bilirubin levels in clinical settings, they do not readily lend themselves to applications outside of hospitals. Consequently, bilirubin monitoring for cirrhotic patients is often performed only intermittently; thus, episodes requiring clinical interventions could be missed. This work investigates the feasibility of measuring bilirubin concentration in whole porcine blood samples using dual-wavelength transmission measurement. A compact and low-cost dual-wavelength ...
Source: IEEE Transactions on Biomedical Engineering - Category: Biomedical Engineering Source Type: research
This study's aim was to examine the accuracy of NSQIP mortality estimates for patients with elevated MELD scores.
Source: American Journal of Surgery - Category: Surgery Authors: Source Type: research
AbstractPurposeTo compare the MRI-derived liver surface nodularity (LSN) scores acquired on both 1.5  T and 3 T.Materials and methodsForty chronic liver disease patients who underwent gadoxetic acid-enhanced MRI at both 1.5 and 3  T were included. Axial hepatobiliary phase images with the same voxel size were used to calculate the LSN score in both liver lobes with a quantitative software. Rank correlation, Wilcoxon test, and Bland–Altman limits of agreement were used for statistical analysis.ResultsThere was a weak correlation between the right and left liver lobe on 1.5  T (rs = 0....
Source: Abdominal Imaging - Category: Radiology Source Type: research
Androutsakos The novel mRNA-based vaccines against SARS-CoV-2 display encouraging safety and efficacy profiles. However, there is a paucity of data regarding their immunogenicity and safety in patients with liver diseases (PWLD), especially in those with cirrhosis. We prospectively assessed anti-SARS-CoV-2 S-spike IgG antibodies and neutralizing activity in fully vaccinated PWLD (n = 87) and controls (n = 40). Seroconversion rates were 97.4% (37/38) in cirrhotic PWLD, 87.8% (43/49) in non-cirrhotic PWLD and 100% (40/40) in controls. Adequate neutralizing activity was detected in 92.1% (35/38), 87.8% (43/49) and 100% (...
Source: Viruses - Category: Virology Authors: Tags: Brief Report Source Type: research
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