Risks and Outcomes of Perioperative Pulmonary Embolism in Major Surgeries: A Population-Based Study

This study aimed to investigate the risks and outcomes of perioperative PE in major surgery.METHODS: Discharge records of the Nationwide Readmission Database from 2010 to 2015 were extracted and analyzed. Length of stay, charges, death, and 30-day hospital readmission rate were compared for patients with and without perioperative PE. In addition, surgery-specific risk factors and therapies associated with PE were explored in a multivariable model.FINDINGS: A total of 12,376,153 hospitalizations for major surgeries were involved, and perioperative PE occurred in 22,676 hospitalizations (0.18%). The length of stay, charges, rate of death, and 30-day hospital readmission were higher in patients with perioperative PE than in those without perioperative PE. Respiratory (odds ratios [OR], 2.09; 95% CI, 1.89-2.3), cardiovascular (OR, 1.62; 95% CI, 1.51-1.73), and musculoskeletal (OR, 1.22; 95% CI, 1.1-1.29) surgeries were risk factors for the occurrence of perioperative PE. In patients with perioperative PE, respiratory surgery was a risk factor for death (OR, 1.48; 95% CI, 1.10-2.00), whereas gynecologic/obstetric surgery was a protective factor for 30-day readmission (OR, 0.30; 95% CI, 0.10-0.88). Regarding therapy for perioperative PE, thrombolytic therapy (OR, 1.74; 95% CI, 1.26-2.42) and embolectomy (OR, 3.60; 95% CI, 2.35-5.51) were risk factors for death.IMPLICATIONS: Respiratory, cardiovascular, and musculoskeletal surgeries were risk factors for the occurrence of perioperat...
Source: Clinical Therapeutics - Category: Drugs & Pharmacology Authors: Source Type: research