Updated reference intervals for urine normetanephrine have no effect on test sensitivity but fewer false positives

CONCLUSIONS: Reference intervals for UNM derived from actual clinical population screening data are higher than in traditional healthy volunteers. Use of these more appropriate reference intervals can significantly reduce the false positive rate without compromising test sensitivity for true pheochromocytoma.PMID:34626610 | DOI:10.1016/j.clinbiochem.2021.09.013

Source: Clinical Biochemistry - October 9, 2021 Category: Biochemistry Authors: Gregory A Kline Jessica Boyd Martin Hyrcza Daniele Pacaud Janice L Pasieka Yuan Dong Hossein Sm Sadrzadeh Alexander Ac Leung Source Type: research