Combining Blood Gene Expression and Cellfree DNA to Diagnose Subclinical Rejection in Kidney Transplant Recipients

CONCLUSIONS: A combination of blood-based biomarkers can improve detection and provide less invasive monitoring for subclinical rejection. In this study, the gene expression profile detected more cellular rejection, whereas donor-derived cfDNA detected more antibody-mediated rejection.PMID:34620649 | DOI:10.2215/CJN.05530421

Source: Clinical Journal of the American Society of Nephrology : CJASN - October 8, 2021 Category: Urology & Nephrology Authors: Sookhyeon Park Kexin Guo Raymond L Heilman Emilio D Poggio David J Taber Christopher L Marsh Sunil M Kurian Steve Kleiboeker Juston Weems John Holman Lihui Zhao Rohita Sinha Susan Brietigam Christabel Rebello Michael M Abecassis John J Friedewald Source Type: research