Expanded Histopathology and Tropism of Ebola Virus in the Rhesus Macaque Model: Potential for Sexual Transmission, Altered Adrenomedullary Hormone Production and Early Viral Replication in liver

This study demonstrates for the first time that Ebola virus causes uterine cervicitis, vaginitis, posthitis, and medullary adrenalitis. Not only is Ebola virus detected in the interstitial stromal cells of the genital tract, but it is also present in the epididymal and seminal vesicular tubular epithelial cells, ectocervical and vaginal squamous epithelial cells, and seminal fluid. Furthermore, as early as day 3 after exposure, EBOV replicative intermediate RNA was detected in Kupffer cells and hepatocytes. These findings in the nonhuman model provide additional insight into potential sexual transmission, possible disruption of sympathetic hormone production, and early virus replication sites in human EVD patients.PMID:34626576 | DOI:10.1016/j.ajpath.2021.09.009

Source: Am J Pathol - October 9, 2021 Category: Pathology Authors: David X Liu Timothy K Cooper Donna L Perry Louis M Huzella Amanda Mw Hischak Randy J Hart Nejra Isic Russell Byrum Danny Ragland Marisa St Claire Kurt Cooper Rebecca Reeder James Logue Peter B Jahrling Michael R Holbrook Richard S Bennett Lisa E Hensley Source Type: research