Epigenetics, the misunderstood science that could shed new light on ageing

The study of the epigenome came with claims that trauma could be inherited, but now researchers are more excited about its potential to measure the risk of diseaseA little over a decade ago, a clutch of scientific studies was published that seemed to show that survivors of atrocities or disasters such as the Holocaust and theDutch famine of 1944-45 had passed on the biological scars of those traumatic experiences to their children.The studies caused a sensation, earning their ownBBCHorizon documentary and the cover ofTime (I also wrote about them, forNew Scientist) – and no wonder. The mind-blowing implications were that DNA wasn’t the only mode of biological inheritance, and that traits acquired by a person in their lifetime could be heritable. Since we receive our full complement of genes at conception and it remains essentially unchanged until our death , this information was thought to be transmitted via chemical tags on genes called “epigenetic marks” that dial those genes’ output up or down. The phenomenon, known as transgenerational epigenetic inheritance, caught the public imagination, in part because it seemed to release us from the tyr anny of DNA. Genetic determinism was dead.Continue reading...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Genetics Biology Science Cancer Dementia Health Medical research Source Type: news