18F-FMISO PET Imaging Identifies Hypoxia and Immunosuppressive Tumor Microenvironments and Guides Targeted Evofosfamide Therapy in Tumors Refractory to PD-1 and CTLA-4 Inhibition

CONCLUSIONS: The results generated from this work provide an immediately translatable paradigm for measuring and targeting hypoxia to increase response to immune checkpoint therapy and using hypoxia imaging to guide combinatory therapies.PMID:34615724 | DOI:10.1158/1078-0432.CCR-21-2394

Source: Clinical Cancer Research - October 7, 2021 Category: Cancer & Oncology Authors: Kirsten M Reeves Patrick N Song Allyson Angermeier Deborah Della Manna Yufeng Li Jianbo Wang Eddy S Yang Anna G Sorace Benjamin M Larimer Source Type: research