Exclusive Expression of MyD88 on Dendritic Cells Is Lopez Kostka Sufficient to Induce Protection against Experimental Leishmaniasis

Leishmania parasites, endemic in (sub)tropical regions, cause a neglected tropical disease affecting ∼12 million cases worldwide. The spectrum of pathologies ranges from cutaneous leishmaniasis to progressive fatal visceral disease. Both in humans and mice, healing is associated with successful development of IFN-γ‒producing T helper type (Th)1/Tc1 cells, whereas Th2-, Th17-, and regulatory T- cell‒predominant responses are associated with progression and/or nonhealing lesions (Kautz-Neu et al., 2011; Sacks and Noben-Trauth, 2002).
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Letters to the Editor Source Type: research