Genome-wide association scan in north Indians reveals three novel HLA-independent risk loci for ulcerative colitis

Conclusions
This study shows varying contribution of the HLA region to UC in different populations. Different environmental exposures and the characteristic genetic structure of the HLA locus across ethnic groups collectively make it amenable to the discovery of causative alleles by transethnic resequencing. This may lead to an improved understanding of the molecular mechanisms underlying UC.

Source: Gut - March 6, 2015 Category: Gastroenterology Authors: Juyal, G., Negi, S., Sood, A., Gupta, A., Prasad, P., Senapati, S., Zaneveld, J., Singh, S., Midha, V., van Sommeren, S., Weersma, R. K., Ott, J., Jain, S., Juyal, R. C., Thelma, B. K. Tags: Ulcerative colitis Inflammatory bowel disease Source Type: research