Viruses, Vol. 13, Pages 2033: Serological Humoral Immunity Following Natural Infection of Children with High Burden Gastrointestinal Viruses
Viruses, Vol. 13, Pages 2033: Serological Humoral Immunity Following Natural Infection of Children with High Burden Gastrointestinal Viruses
Viruses doi: 10.3390/v13102033
Authors:
Mark R. Zweigart
Sylvia Becker-Dreps
Filemón Bucardo
Fredman González
Ralph S. Baric
Lisa C. Lindesmith
Acute gastroenteritis (AGE) is a major cause of morbidity and mortality worldwide, resulting in an estimated 440,571 deaths of children under age 5 annually. Rotavirus, norovirus, and sapovirus are leading causes of childhood AGE. A successful rotavirus vaccine has reduced rotavirus hospitalizations by more than 50%. Using rotavirus as a guide, elucidating the determinants, breath, and duration of serological antibody immunity to AGE viruses, as well as host genetic factors that define susceptibility is essential for informing development of future vaccines and improving current vaccine candidates. Here, we summarize the current knowledge of disease burden and serological antibody immunity following natural infection to inform further vaccine development for these three high-burden viruses.
Source: Viruses - Category: Virology Authors: Mark R. Zweigart Sylvia Becker-Dreps Filem ón Bucardo Fredman Gonz ález Ralph S. Baric Lisa C. Lindesmith Tags: Review Source Type: research
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