Chronic Graft-Versus-Host Disease, Non-Relapse Mortality and Disease Relapse in Older versus Younger Adults Undergoing Matched Allogeneic Peripheral Blood Hematopoietic Cell Transplantation: A CIBMTR Analysis

Chronic graft-versus-host disease (cGVHD) is a major late complication of allogeneic hematopoietic cell transplantation (alloHCT). Chronic GVHD is associated with higher transplant-related morbidity, mortality, infectious complications, prolonged duration of immune suppression, and impaired patient-reported quality of life.1-4 Chronic GVHD represents a major obstacle to recovery and survival following alloHCT. Additionally, a 2015 CIBMTR study demonstrated an increasing incidence of cGVHD including moderate and severe cGVHD, in part related to an increase in number of older adults undergoing HCT, improvement in survival and use of peripheral blood stem cell grafts.

Source: Biology of Blood and Marrow Transplantation - October 9, 2021 Category: Hematology Authors: Vijaya Raj Bhatt, Tao Wang, Karen Chen, Carrie L. Kitko, Margaret L. MacMillan, Joseph A. Pidala, Monzr M. Al Malki, Sherif M. Badawy, Amer Beitinjaneh, Siddhartha Ganguly, Betty Hamilton, Gerhard C. Hildebrandt, Lazaros J. Lekakis, Hongtao Liu, Richard T Source Type: research