Expression of PIAS Genes in Migraine Patients

AbstractMigraine is a complex disabling condition which is associated with dysregulation of several pathways particularly those being associated with immune responses. In order to assess contribution of protein inhibitor of activated STAT (PIAS) in the pathogenesis of migraine, we quantified expression levels ofPIAS1–PIAS4 genes in the circulation of patients with migraine compared with controls. Expression ofPIAS1 was substantially lower in total migraineurs compared with controls (ratio of mean expressions (RME)  = 0.18, SE = 0.29,P value  <  0.001) and in both male and female migraineurs compared with sex-matched controls. Expression ofPIAS2 was lower in migraineurs without aura compared with controls (RME  = 0.64, SE = 0.31,P value  = 0.04) and in male subgroup of these patients compared with male controls (RME = 0.60, SE = 0.22,P value  <  0.001). In migraineurs with aura, downregulation ofPIAS2 was only observed among male subgroups (RME  = 0.37, SE = 0.49,P value  = 0.01).PIAS3 was downregulated in total male migraineurs (RME  = 0.52, SE = 0.43,P value  = 0.04) and in male migraineurs with aura (RME = 0.49, SE = 0.45,P value  = 0.03) compared with male controls. Finally,PIAS4 was upregulated in total migraineurs (RME  = 3.78, SE = 0. 34,P value  <  0.001), female migraineurs (RME = 5.26, SE = 0.36,P value  <  0.001), migraineurs with aura (RME = 4.24, SE ...
Source: Journal of Molecular Neuroscience - Category: Neuroscience Source Type: research