Perinatal Outcomes Among Patients With Sepsis During Pregnancy

This study found that pregnancies with antepartum sepsis were associated with higher odds of complications that are associated with placental dysfunction, suggesting that increased antenatal surveillance may be warranted for these patients. Importance: Rates of maternal sepsis are increasing, and prior studies of maternal sepsis have focused on immediate maternal morbidity and mortality associated with sepsis during delivery admission. There are no data on pregnancy outcomes among individuals who recover from their infections prior to delivery. Objective: To describe perinatal outcomes among patients with antepartum sepsis who did not deliver during their infection hospitalization. Design, Setting, and Participants: This retrospective cohort study was conducted using data from August 1, 2012, to August 1, 2018, at an academic referral center in San Francisco, California. Included patients were all individuals with nonanomalous, singleton pregnancies who delivered after 20 weeks'gestation during the study period. Data were analyzed from March 2020 through March 2021. Exposures: Antepartum admission for infection with clinical concern for sepsis and hospital discharge prior to delivery. Main Outcomes and Measures: The primary outcome was a composite of perinatal outcomes associated with placental dysfunction and consisted of 1 or more of the following: fetal growth restriction, oligohydramnios, hypertensive disease of pregnancy, cesarean delivery for fetal indication, child who...
Source: Current Awareness Service for Health (CASH) - Category: Consumer Health News Source Type: news

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As fetal gene therapies move from experimental animal models to human in utero phase I clinical trials, there is a need to consider the ethical, legal, and social implications. While fetal gene therapies are attracting more regulatory oversight than previous fetal interventions such as fetal surgery, old sociological questions should be applied to this new context. As health care pathways around fetal therapy are shaped by the ways in which a pregnant person and the fetus are constituted, and as risks and benefits are evaluated, we cannot afford to lose sight of long-term consequences, especially those pertaining to social inclusion.
Source: Clinical Obstetrics and Gynecology - Category: OBGYN Tags: Gene Therapy in Obstetrics Source Type: research
The Food and Drug Administration is helping women and their health care providers to learn more about the effects of medicines during pregnancy and breastfeeding.
Source: FDA Center for Drug Evaluation and Research - What's New - Category: Drugs & Pharmacology Authors: Source Type: news
By Alfred Okiria, Project director, South Sudan ; Katherine Seaton, Communications writer/editor, IntraHealth International A nurse draws blood to test for HIV and begins counseling a client at the Saint Bakhita Health Centre in Yei, South Sudan. Photo by Trevor Snapp for IntraHealth International.October 21, 2021What does it take to keep HIV services available despite limited resources, political unrest and violence, and a pandemic?For Alfred Okiria, IntraHealth International’s project director for theStrengthening National Capacity for Integrated HIV/AIDS Health Data Collection, Use, and Dissemination in Supp...
Source: IntraHealth International - Category: International Medicine & Public Health Authors: Tags: HIV & AIDS Digital Health Measurement Analytics Source Type: news
Ghalandari et al. sought to validate the guidance outlined by EULAR for the use of anti-rheumatic drugs during pregnancy, finding that following its guidance for tumor necrosis factor inhibitors led to no or low concentrations of these agents in cord blood.
Source: The Rheumatologist - Category: Rheumatology Authors: Tags: DMARDs & Immunosuppressives Drug Updates EULAR pregnancy pregnant women TNF inhibitors TNFi Source Type: research
Bipolar disorder (BD) is linked to a high risk of relapse in the year postpartum. The aim of this study was to search for an association of a mood episode during pregnancy with a lack of maternal improvement after a post-partum episode requiring joint hosp...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Infants and Children Source Type: news
Condition:   Prenatal Stress Intervention:   Behavioral: Virtual Mindfulness Meditation Sponsor:   University of Pennsylvania Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Fetal Growth Retardation Intervention:   Other: . Pesticide and Pharmaceutical analysis Sponsor:   Kutahya Health Sciences University Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
[Daily News] PREGNANT women may breathe a sigh of relief following ongoing efforts to construct and repair 34 health facilities to improve health services, including the Comprehensive Emergency Obstetric and Newborn Care (CEmONC) in Rukwa region.
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
Everly Health continues its acquisitive 2021 with the purchase of Natalist, a women's health startup that offers conception and pregnancy essentials for a community of thousands. The acquisition marks the all-too-rare combination of two female-lead companies at a time when equity is center stage on Austin's startup scene.
Source: bizjournals.com Health Care:Pharmaceuticals headlines - Category: Pharmaceuticals Authors: Source Type: news
Source: BMJ Comments - Category: General Medicine Source Type: forums
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